Financiado en parte por Ferrarelle spa
Beneficial Effects of Long-Lasting Bicarbonate-Sulfate-Calcium-Magnesium Water Intake on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Outcomes via Impacting Intestinal Permeability (IP), IP-Related Systemic Inflammation, and Oxidative Stress
Dallio M, Romeo M, Di Nardo F, Senese G, Silvestrin A, Coppola A, Napolitano C, Vaia P, Basile C, Martinelli G, Gregorio A, Federico A
Nutrients · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Università degli Studi della Campania Luigi Vanvitelli
- Universidad u hospital
- Department of Precision Medicine of the University of Campania “Luigi Vanvitelli”
- Empresa
- Ferrarelle spa
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-10-31 · Nutrients · vol. 17 · número 21 · pág. 3452
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 4 citas · más que el 90% de estudios similares · 2.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Gut microbiota and health · Alcohol Consumption and Health Effects
- Palabras clave
- non-alcoholic fatty liver disease, mineral water, bicarbonate, sulfate, calcium, magnesium, intestinal permeability, gut-liver axis, systemic inflammation, oxidative stress, lipopolysaccharide, controlled attenuation parameter, hepatic steatosis, occludin, claudin-1
- MeSH
- intestinal mucosa, humans, fatty liver, inflammation, bicarbonates, sulfates, calcium, magnesium, haptoglobins, protein precursors, treatment outcome, oxidative stress, permeability, adult, aged, middle aged, female, male, non-alcoholic fatty liver disease, intestinal barrier function
12 autores
- Marcello Dallio🇮🇹University of Campania "Luigi Vanvitelli"
- Mario Romeo🇮🇹 · autor de correspondenciaUniversity of Campania "Luigi Vanvitelli"
- Fiammetta Di Nardo🇮🇹University of Campania "Luigi Vanvitelli"
- Giusy Senese🇮🇹University of Campania "Luigi Vanvitelli"
- Alessia Silvestrin🇮🇹University of Campania "Luigi Vanvitelli"
- Annachiara Coppola🇮🇹University of Campania "Luigi Vanvitelli"
- Carmine Napolitano🇮🇹University of Campania "Luigi Vanvitelli"
- Paolo Vaia🇮🇹University of Campania "Luigi Vanvitelli"
- Claudio Basile🇮🇹University of Campania "Luigi Vanvitelli"
- Giuseppina Martinelli🇮🇹University of Campania "Luigi Vanvitelli"
- Alessia De Gregorio🇮🇹University of Campania "Luigi Vanvitelli"
- Alessandro Federico🇮🇹University of Campania "Luigi Vanvitelli"
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Fonte Essenziale®, a mineral water rich in bicarbonate, sulfate, calcium, and magnesium, has shown potential in modulating the gut-liver axis and microbiota in hepatic steatosis. However, its long-term effects on intestinal permeability (IP), systemic inflammation (SI), and oxidative stress-key factors in Metabolic dysfunction-associated steatotic liver disease (MASLD)-remain unexplored. Methods: Eighty-seven MASLD patients were randomized into two groups: group A received Fonte Essenziale® (400 mL/day, fasting) plus a controlled nutritional regimen for 12 months, followed by a 6-month water washout; group B followed only the controlled nutritional regimen. IP markers, SI (IL-1β, IL-6, TNF-α), oxidative stress (dROMs/BAP), and clinical data (including Controlled Attenuation Parameter-CAP) were assessed at baseline (T0), 12 months (T12), and post-washout (T18). Baseline increased IP (in-IP) was defined by fecal zonulin > 110 ng/mL and serum LBPp > 10 µg/mL; improvement (im-IP) required normalization of both. A ≥30% CAP reduction indicated steatosis improvement. Results: Thirty-eight patients in group A and thirty-nine in group B completed the study. At T12, group A showed significant reductions in fecal zonulin (p: 0.0163) and serum LBPp (p p p: 0.0037). Group A also showed significant reductions in IL-1β, TNF-α, IL-6, LPS, and dROM/BAP (all p p p: 0.001) and im-IP achievement (aHR: 1.267, p: 0.021) as predictors of steatosis improvement. Benefits persisted at T18. Conclusions: Prolonged Fonte Essenziale® intake improved hepatic steatosis and MASLD outcomes by modulating IP, SI, and oxidative stress. This trial has been registered on clinicaltrials.gov (NCT07211113).
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