Ultraprocessed Food Consumption and Risk of Early-Onset Colorectal Cancer Precursors Among Women
Wang C, Du M, Kim H, Nguyen LH, Wang QL, Drew DA, Leeming ER, Khandpur N, Sun Q, Zong X, Gweon TG, Ogino S, Ng K, Berry S, Giovannucci EL, Song M, Cao Y, Chan AT
JAMA oncology · 29 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- NCI NIH HHS
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-11-13 · JAMA Oncol · vol. 12 · número 1 · pág. 49
- Editorial
- American Medical Association
- Citado
- 30 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Colorectal Cancer Screening and Detection · Nutritional Studies and Diet · Consumer Attitudes and Food Labeling
- Palabras clave
- Colorectal cancer, MEDLINE, Food consumption, Consumption (sociology), Carcinogenesis, Colonic disease, Food group, Food intake
- MeSH
- humans, adenoma, colorectal neoplasms, diet, incidence, risk factors, prospective studies, feeding behavior, age of onset, food handling, adult, middle aged, female
18 autores
- Chen Wang🇺🇸Harvard University; Massachusetts General Hospital
- Mengxi Du🇺🇸Harvard University; Massachusetts General Hospital
- Hanseul Kim🇺🇸Harvard University; Massachusetts General Hospital
- Long H. Nguyen🇺🇸Harvard University; Massachusetts General Hospital
- Qiao-Li Wang🇺🇸Harvard University; Dana-Farber Cancer Institute
- David A. Drew🇺🇸Harvard University; Massachusetts General Hospital
- Emily R. Leeming🇬🇧King's College London
- Neha Khandpur🇺🇸🇧🇷🇳🇱Harvard University; Universidade de São Paulo; Wageningen University & Research
- Qi Sun🇺🇸Brigham and Women's Hospital; Harvard University
- Xiaoyu Zong🇺🇸Washington University in St. Louis
- Tae‐Geun Gweon🇺🇸🇰🇷Massachusetts General Hospital; Catholic University of Korea
- Shuji Ogino🇺🇸🇯🇵Broad Institute; Tokyo Medical and Dental University; Brigham and Women's Hospital; Harvard University; Dana-Farber/Harvard Cancer Center
- Kimmie Ng🇺🇸Harvard University; Dana-Farber Cancer Institute
- Sarah E. Berry🇬🇧King's College London
- Edward L. Giovannucci🇺🇸Harvard University
- Mingyang Song🇺🇸Harvard University; Massachusetts General Hospital
- Yin Cao🇺🇸Washington University in St. Louis; Alvin J. Siteman Cancer Center
- Andrew Tan Chan🇺🇸Brigham and Women's Hospital; Harvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Importance
Early-onset colorectal cancer (EOCRC) (diagnosed age <50 years) incidence is increasing globally, in parallel with increased consumption of ultraprocessed foods (UPFs). The role of UPFs in early-onset colorectal neoplasia remains underexplored.
Objective
To evaluate the association between UPF consumption and risk of EOCRC precursors.
Design, setting, and participants
This prospective cohort study included participants of the Nurses' Health Study II, an ongoing US prospective cohort of female registered nurses established in 1989. Participants were followed up from June 1, 1991, through June 1, 2015. Data were analyzed from October 2024 to July 2025. UPF intake, derived from food-frequency questionnaires administered every 4 years and classified using the Nova system, was modeled as quintiles of energy-adjusted servings per day. Of the nurses enrolled, those who had completed the baseline 1991 food-frequency questionnaire, undergone at least 1 lower endoscopy before age 50 years after baseline, had no history of cancer (except for nonmelanoma skin cancer) before endoscopy, and no colorectal polyp or inflammatory bowel disease were included.
Main outcomes and measures
Incidence of EOCRC precursors, including conventional adenomas and serrated lesions, confirmed via medical records and pathology reports. Multivariable logistic regression models with generalized estimating equations for clustered data were used to estimate adjusted odds ratios (AORs) and 95% CIs, accounting for known and putative risk factors.
Results
Among 29 105 female participants (mean [SD] age, 45.2 [4.5] years) over 24 years of follow-up, 1189 cases were documented of early-onset conventional adenomas and 1598 serrated lesions. UPFs provided 34.8% of total daily calories (median, 5.7 [IQR, 4.5-7.4] servings per day). Participants with higher UPF intake had an increased risk of early-onset conventional adenomas (highest vs lowest intake: AOR, 1.45; 95% CI, 1.19-1.77; overall P < .001) but not serrated lesions (AOR, 1.04; 95% CI, 0.89-1.22; P = .48 for trend). Findings were consistent after further adjustment for body mass index, type 2 diabetes, dietary factors (fiber, folate, calcium, and vitamin D), and Alternative Healthy Eating Index-2010 score.
Conclusions and relevance
In this study, higher UPF intake was associated with increased risk of early-onset colorectal conventional adenomas. These data highlight the important role of UPFs in early-onset colorectal tumorigenesis and support improving dietary quality as a strategy to mitigate the increasing burden of EOCRC.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.