Higher consumption of ultra-processed foods and long-term risk of metabolic dysfunction-associated steatotic liver disease and primary liver cancer: A meta-analysis of preliminary evidence
Souza M, Lima LCV, Amaral MJM, Moura FS
Clinical nutrition ESPEN · 3 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-11-20 · Clin Nutr ESPEN · vol. 72 · pág. 102819
- Editorial
- Elsevier BV
- Citado
- 8 citas · más que el 89% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Food composition and properties
- Palabras clave
- Consumption (sociology), Disease, Liver disease, Fatty liver, Metabolic syndrome
- MeSH
- humans, liver neoplasms, fatty liver, diet, risk factors, female, male, fast foods, food, processed
4 autores
- Matheus Henrique Gonçalves de Souza🇧🇷 · autor de correspondenciaUniversidade Federal do Rio de Janeiro
- Luan C V Lima🇧🇷Universidade Federal do Rio de Janeiro
- Marcio J M Amaral🇧🇷Universidade Federal do Rio de Janeiro
- Felipe S. Moura🇧🇷Universidade Federal do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ultra-processed foods (UPFs) are a major component of the Western diet, and their consumption is increasing worldwide. Although there is compelling evidence for the effects of UPF on non-communicable diseases, data on their long-term effects on liver health are limited.
Methods
We systematically searched PubMed and Embase (from 2009 to September 5, 2025) for prospective cohort studies assessing the association between higher UPF consumption (defined by the NOVA 4 classification) and the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) and primary liver cancer outcomes. Meta-analysis was performed using a random-effects model with the restricted maximum likelihood estimator and Knapp-Hartung adjustment to obtain pooled adjusted hazard ratios (HR) with 95 % confidence intervals (CIs).
Results
We included 7 studies with a total of 1,272,317 participants. The highest UPF consumption was significantly associated with an increased long-term risk of MASLD (pooled HR 1.32, 95 % CI 1.11 to 1.58). Moreover, the available evidence suggests no statistically significant association of higher UPF consumption and the long-term risk of developing primary liver cancer (pooled HR 1.21, 95 % CI 0.52 to 2.79), including hepatocellular carcinoma (pooled HR 0.98, 95 % CI 0.66 to 1.45) and intrahepatic cholangiocarcinoma (HR 1.00, 95 % CI 0.50 to 2.03). Sensitivity analyses did not modify these results. When UPF consumption was analyzed as a continuous variable, we found three cohort studies demonstrating its significant association with increased risk of MASLD and three cohort studies reporting conflicting results for primary liver cancer.
Conclusions
These preliminary findings suggest that higher consumption of UPFs may contribute to an increased long-term risk of MASLD, highlighting the potential benefits of reducing UPF intake as part of preventive strategies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.