Associations of calcium and magnesium intakes and their intake ratio with albuminuria in middle-aged and older adults
Kabasawa K, Hosojima M, Nakamura K, Takachi R, Sawada N, Tsugane S, Tanaka J, Yamamoto S, Ito Y
PloS one · 0 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Japan Society for the Promotion of Science
- Subvenciones
- Japan Society for the Promotion of Science (17K15850); Japan Society for the Promotion of Science (23K07694)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-26 · PLoS One · vol. 20 · número 11 · pág. e0335412
- Editorial
- Public Library of Science
- Citado
- 1 cita · más que el 69% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Sodium Intake and Health
- Palabras clave
- Calcium, Magnesium, Albuminuria, Renal function, Population, Cohort, Urinary calcium, Logistic regression
- MeSH
- humans, albuminuria, calcium, dietary, calcium, magnesium, creatinine, glomerular filtration rate, cross-sectional studies, adult, aged, middle aged, japan, female, male
9 autores
- Keiko Kabasawa🇯🇵 · autor de correspondenciaNiigata University Medical and Dental Hospital; Niigata University
- Michihiro Hosojima🇯🇵Niigata University Medical and Dental Hospital; Niigata University
- Kazutoshi Nakamura🇯🇵Niigata University Medical and Dental Hospital; Niigata University
- Ribeka Takachi🇯🇵Nara Women's University
- Norie Sawada🇬🇧National Cancer Research Institute
- Shoichiro Tsugane🇯🇵International University of Health and Welfare
- Junta Tanaka🇯🇵Niigata University Medical and Dental Hospital; Niigata University
- Suguru Yamamoto🇯🇵Niigata University Medical and Dental Hospital
- Yumi Ito🇯🇵Niigata University Medical and Dental Hospital; Niigata University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Calcium and magnesium both work together and against each other by sharing homeostatic regulatory systems in the kidneys. Previous studies suggested that these minerals and their intake ratio were associated with chronic health conditions such as cardiovascular disease. Our objective was to investigate the association of calcium and magnesium intake and their intake ratio with albuminuria. This cross-sectional study analyzed data from a Japanese community-based cohort comprising 6,849 individuals aged ≥40 years (mean age 68.8 years, 51.3% women). Energy-adjusted dietary intake of calcium and magnesium and the calcium-to-magnesium intake ratio were derived from a validated food frequency questionnaire. The outcome was spot urinary albumin-to-creatinine ratio (ACR, mg/g). Linear and logistic regression analyses were performed with adjustments for potential confounders. The analytic population had 1.65 and 73.5 mL/min/1.73 m2 as median intake ratio and estimated glomerular filtration rate, respectively. In multivariable linear regression analysis, lower intakes of calcium and magnesium were associated with the log-transformed ACR but, after mutual adjustment, only calcium intake was independently associated with the ACR (regression coefficient -0.084; 95%CI, -0.149, -0.019). A lower intake ratio was associated with the log-transformed ACR (regression coefficient, -0.085; 95%CI, -0.150, -0.021). These associations were evident overall and in male participants. Although magnesium intake was associated with albuminuria only before accounting for calcium intake, calcium intake and calcium-to-magnesium intake ratio demonstrated robust associations. Our findings support that the importance of calcium intake and its balancing with magnesium might extend to kidney health, especially albuminuria.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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