Intermittent Fasting During Pregnancy and Neonatal Birth Weight: A Systematic Review and Meta-Analysis
Giorno A, De Simone C, Lopez G, Pisaturo ML, Niccolini L, Guida M, Sarno L, Schettini SCA
Nutrients · 1 cita
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-13 · Nutrients · vol. 17 · número 22 · pág. 3546
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 1 cita · más que el 44% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Birth, Development, and Health · Maternal and Neonatal Healthcare
- Palabras clave
- intermittent fasting, Ramadan fasting, pregnancy, birth weight, low birth weight, maternal diet, pregnancy outcomes
- MeSH
- humans, birth weight, pregnancy outcome, fasting, pregnancy, infant, newborn, infant, low birth weight, female, intermittent fasting
8 autores
- Alice Giorno🇮🇹 · autor de correspondenciaOspedale San Carlo; University of Naples Federico II
- Concetta De Simone🇮🇹Ospedale San Carlo; University of Naples Federico II
- Giovanni Lopez🇮🇹Ospedale San Carlo; University of Naples Federico II
- M. L. Pisaturo🇮🇹Ospedale San Carlo
- Ludovica Niccolini🇮🇹University of Naples Federico II
- Maurizio Guida🇮🇹University of Naples Federico II
- Laura Sarno🇮🇹University of Naples Federico II
- Sergio C. A. Schettini🇮🇹Ospedale San Carlo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Intermittent fasting (IF), such as Ramadan fasting, is common among pregnant women despite religious exemptions. The possible impact of fasting on pregnancy outcome and, in particular, on birthweight is uncertain and was documented with conflicting evidence. Methods: The aim of this meta-analysis and systematic review was to investigate the association between intermittent fasting during pregnancy and neonatal birthweight, along with low birthweight (LBW, 2 statistic. Results: Nineteen studies, all observational in design, were included for qualitative synthesis, and six studies yielded quantitative data to conduct meta-analyses. No randomized controlled trials were identified. Intermittent fasting during pregnancy, encompassing more than 1.3 million pregnancies, was associated with a small but statistically significant reduction in neonatal birth weight. The pooled mean difference was -94 g (95% CI: -176 to -12 g; p = 0.03; I2 = 70%), indicating a minor but statistically significant effect that is unlikely to be clinically meaningful. The pooled RR for LBW was 0.96 (95% CI: 0.88-1.05; p = 0.38; I2 2 ≈ 55%) and confirmed the robustness of these findings. According to the GRADE approach, the certainty of evidence was moderate for birthweight and high for LBW. Conclusions: Intermittent fasting during pregnancy, including Ramadan fasting, was associated with a minor but statistically significant reduction in neonatal birthweight without increasing the risk of low birthweight. This difference was small and clinically negligible. Further prospective studies are needed to clarify trimester-specific effects and long-term developmental outcomes.
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