Flexible time-restricted eating combined with exercise in a free-living setting for middle-aged women with overweight/obesity: a randomized controlled trial
Dai Z, Miyashita M, Poon ET, Tian XY, Yu AP, Sit CH, Wong SH
Nature communications · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-27 · Nat Commun · vol. 16 · número 1 · pág. 10659
- Editorial
- Nature Portfolio
- Citado
- 5 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Obesity, Physical Activity, Diet · Diet and metabolism studies
- Palabras clave
- aerobic exercise, obesity, overweight, middle-aged women, fat mass reduction, body composition, metabolic health, menopause
- MeSH
- humans, obesity, treatment outcome, exercise, body composition, adult, middle aged, hong kong, female, overweight
7 autores
- Zi-Han Dai🇭🇰Chinese University of Hong Kong
- Masashi Miyashita🇬🇧🇯🇵🇭🇰Loughborough University; Waseda University; Chinese University of Hong Kong
- Eric Tsz‐Chun Poon🇭🇰Chinese University of Hong Kong
- Xiao Yu Tian🇭🇰Chinese University of Hong Kong
- Angus P. Yu🇭🇰Chinese University of Hong Kong
- Cindy H. P. Sit🇭🇰Chinese University of Hong Kong
- Stephen Heung‐Sang Wong🇭🇰Chinese University of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity poses a significant public health challenge among middle-aged women, driven by physiological changes associated with aging and menopause. This parallel-group, assessor-blinded, four-arm randomized controlled trial investigated the effects of 12-week 8-hour flexible time-restricted eating (flexTRE) and aerobic exercise (EX), alone or in combination (flexTRE+EX), on body composition and metabolic health in a free-living setting. Participant enrolment began on September 1st 2023 and data collection was completed on July 1st 2024. Conducted at a single research site in Hong Kong, the trial enrolled women aged 40-60 years with overweight/obesity. Participants were randomized in a 1:1:1:1 ratio to a flexTRE, EX, flexTRE+EX, or control (CON) group (n = 26 per group), with all 104 participants included in the final intention-to-treat analysis. Outcomes were assessed at baseline, and week 12. The primary outcome was fat mass. The flexTRE+EX group achieved the greatest fat mass reduction compared to the CON group (adjusted mean difference [99% Confidence Interval] -2.85 kg [-4.01 to -1.69]), and additional benefit over the flexTRE group alone (-1.56 kg [-2.74 to -0.38]), and the EX group alone (-2.01 kg [-3.21 to -0.81]). Secondary outcomes were reported in the main text. No serious adverse events were reported, and adherence was high (83%-87%) across intervention groups. These findings suggest that the combined approach effectively reduces fat mass and enhances related metabolic parameters, providing a feasible and effective strategy in middle-aged women facing overweight/obesity. Trial registration: ChiCTR2300074846.
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