Effects of 15:9 time-restricted eating on cognitive function and anthropometric parameters among the elderly with mild cognitive impairment: an assessor-blinded, pilot randomized controlled trial
Wang J, Wang F, Shi M, Chen H, Liu Q, Liu L, Xu X, He C, Xu L, Hu X
BMC geriatrics · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Sichuan University
- Organización sin fines de lucro
- Chinese Medical Association
- Universidad u hospital
- the West China Nursing Discipline Development Special Fund Project, Sichuan University
- Universidad u hospital
- the nursing discipline of the Journal of Chinese Medical Association
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-27 · BMC Geriatr · vol. 25 · número 1 · pág. 1063
- Editorial
- BioMed Central
- Citado
- 3 citas · más que el 85% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- time-restricted eating, mild cognitive impairment, older adults, cognitive function, anthropometric parameters, body mass index, waist circumference, dietary adherence, auditory verbal learning, attention, ad libitum feeding, community-dwelling older adults, Montreal Cognitive Assessment, calf circumference, body weight
- MeSH
- humans, anthropometry, body mass index, pilot projects, single-blind method, cognition, time factors, aged, aged, 80 and over, china, female, male, cognitive dysfunction
10 autores
- Jun Wang🇨🇳Zunyi Medical University; Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Fang Wang🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Meihong Shi🇨🇳Sichuan University; West China Medical Center of Sichuan University; Southwest Medical University; West China Hospital of Sichuan University
- Hongxiu Chen🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Qingquan Liu🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Li Liu🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Xueqiong Xu🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
- Chunxia He🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University; Third People's Hospital of Chengdu
- Lisheng Xu🇨🇳Sichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University; State Key Laboratory of Oral Diseases
- Xiuying Hu🇨🇳 · autor de correspondenciaSichuan University; West China Medical Center of Sichuan University; West China Hospital of Sichuan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effects of 15:9 time-restricted eating (TRE) on cognitive function and anthropometric parameters among the elderly with mild cognitive impairment (MCI) requires further investigation.
Objective
This assessor-blinded, pilot randomized controlled trial aimed to examine the effects of 12 weeks of 15:9 TRE on cognitive function and anthropometric parameters in older adults with MCI.
Methods
Forty-six eligible participants (mean age 74.20 ± 5.09 years) were recruited from a community elderly service center in Chengdu, Sichuan, China, and were randomly allocated to either the TRE group (n = 23) or the control group (n = 23). The TRE group followed 15:9 TRE for 12 weeks and the control group maintained eating ad libitum without any modifications. The primary outcome were changes in the Montreal Cognitive Assessment (MoCA) and the auditory verbal learning test-Huashan version (AVLT-H) and their subitems. The secondary outcome were changes in body weight, body mass index (BMI), waist circumference, calf circumference, and adherence. All outcomes, except for adherence, were measured consistently at baseline, 6 weeks, and 12 weeks.
Results
There was a significant improvement in the MoCA total score (from baseline to 6-week: β = 1.22, 95% CI: 0.33 to 2.10, P = 0.007; from baseline to 12-week: β = 1.70, 95% CI: 0.46 to 2.94, P = 0.007) and the attention score of MoCA (from baseline to 6-week: β = 0.65, 95% CI: 0.15 to 1.15, P = 0.011) in the TRE group compared with the control group. The AVLT-H recognition score (AVLT-H-REC-S) was significantly improved in the TRE group compared with the control group (from baseline to 12-week: β = 2.44, 95% CI: 0.63 to 4.24, P = 0.008). There was no significant difference in body weight, BMI, waist circumference, or calf circumference between the two groups. The mean adherence to TRE was more than 5 days per week in the TRE group.
Conclusions
Short-term improvements in MoCA total score and AVLT-H-REC-S were observed among elderly individuals with MCI following a 12-week 15:9 TRE. However, no significant effect of TRE on anthropometric parameters was found. These findings should be interpreted with caution due to the limited sample size. Larger-sample studies are needed to further clarify the underlying mechanisms by which TRE affects cognitive function in the elderly MCI population.
Trial registration
This trial was registered at the China Clinical Trial Registration Center on 5 November 2021, with registration number ChiCTR2100052766.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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