Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post-Thyroidectomy
Tabriz N, Fried D, Uslar V, Weyhe D
Endocrinology, diabetes & metabolism · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-30 · Endocrinol Diabetes Metab · vol. 9 · número 1 · pág. e70129
- Editorial
- Bioscientifica
- Citado
- 0 citas · más que el 45% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Thyroid and Parathyroid Surgery · Thyroid Disorders and Treatments · Parathyroid Disorders and Treatments
- Palabras clave
- postoperative hypocalcemia, hypoparathyroidism, thyroidectomy, quality of life, Graves' disease, nodular goiter, vitamin D deficiency, parathyroid hormone, EQ-5D
- MeSH
- humans, hypocalcemia, hypoparathyroidism, goiter, nodular, postoperative complications, calcium carbonate, calcium, magnesium, preoperative care, thyroidectomy, quality of life, dietary supplements, adult, middle aged, female, graves disease, male
4 autores
- Navid Tabriz🇩🇪 · autor de correspondenciaCarl von Ossietzky Universität Oldenburg; Pius Hospital Oldenburg
- Dennis Fried🇩🇪Carl von Ossietzky Universität Oldenburg; Pius Hospital Oldenburg
- Verena Uslar🇩🇪Carl von Ossietzky Universität Oldenburg; Pius Hospital Oldenburg
- Dirk Weyhe🇩🇪Carl von Ossietzky Universität Oldenburg; Pius Hospital Oldenburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Postoperative hypocalcemia and hypoparathyroidism are common complications after thyroidectomy, often impairing quality of life (QoL). This study investigates the impact of preoperative calcium and magnesium supplementation on postoperative QoL and hypocalcemia in patients undergoing total thyroidectomy for symptomatic nodular goitre or Graves' disease.
Methods
A total of 62 patients undergoing thyroidectomy for benign thyroid diseases were randomised into two groups. The intervention group (IG, n = 31) received 500 mg calcium carbonate thrice daily and 300 mg magnesium carbonate once daily for 2 weeks preoperatively, while the control group (CG, n = 31) received no supplementation. Laboratory parameters (Ca, Mg, PTH, 25-OH-Vitamin D) were measured at study enrolment (T1), preoperatively (T2), immediately postoperatively (T3) and 6 weeks post-discharge (T4). QoL was assessed using EQ-5D and ThyPro39de questionnaires.
Results
QoL significantly improved postoperatively in both groups. Patients with Graves' disease in the IG reported earlier QoL improvements immediately post-surgery (T3). Postoperative hypocalcemia occurred in 19.4% of IG patients and 25% of CG patients, with hypoparathyroidism in 16% and 23%, respectively. The IG demonstrated higher postoperative calcium levels and fewer hypocalcemia symptoms, especially in Graves' disease patients (not significant). Vitamin D deficiency was prevalent (66.7%) but showed no correlation with hypocalcemia.
Discussion
Preoperative calcium and magnesium supplementation might have positive effects on postoperative QoL, especially in Graves' disease patients, and may reduce hypocalcemia symptoms. This simple, inexpensive and low-risk intervention may be beneficial in the preoperative setting prior to thyroidectomy. Although the observed effect did not reach statistical significance, it could still be of clinical relevance. The additional benefit of preoperative magnesium supplementation seems to be of minor significance, while the effect of pre-existing vitamin D deficiency remains uncertain.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.