The effectiveness of red-light therapy on myopia control depends on its direct effect: a mediation analysis
Chen Q, Wei H, Soh ZD, Zhu Q, Shao X, Xue C, Li H, Tao Y, Hu M, Cheng CY, Zhong H
Journal of translational medicine · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China-Yunnan Joint Fund
- Subvenciones
- National Natural Science Foundation of China-Yunnan Joint Fund (82360212)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-12-02 · J Transl Med · vol. 24 · número 1 · pág. 34
- Editorial
- BioMed Central
- Citado
- 2 citas · más que el 82% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Palabras clave
- Peripheral, Refraction, Mediation, Retinal, Randomized controlled trial, Choroid, Refractive error
- MeSH
- choroid, humans, myopia, refraction, ocular, treatment outcome, child, female, male, red light
11 autores
- Qin Chen🇨🇳Nanjing Medical University
- Hongyu Wei🇨🇳🇸🇬Kunming Medical University; Singapore Eye Research Institute; First Affiliated Hospital of Kunming Medical University
- Zhi Da Soh🇸🇬Singapore Eye Research Institute
- Qin Zhu🇨🇳Yunnan University; Second People's Hospital of Yunnan Province
- Xian Shao🇨🇳Kunming Medical University; First Affiliated Hospital of Kunming Medical University
- Cancan Xue🇸🇬Singapore Eye Research Institute
- Hengtong Li🇸🇬Singapore Eye Research Institute
- Yijin Tao🇨🇳Kunming Medical University; First Affiliated Hospital of Kunming Medical University
- Min Hu🇨🇳Yunnan University; Second People's Hospital of Yunnan Province
- Ching‐Yu Cheng🇸🇬National University of Singapore; Singapore Eye Research Institute; Duke-NUS Medical School; National University Health System
- Hua Zhong🇨🇳 · autor de correspondenciaKunming Medical University; First Affiliated Hospital of Kunming Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
PURPOSE: To investigate whether alterations in subfoveal choroidal thickness (SFCT) and peripheral retinal refraction mediate the efficacy of repeated low-level red-light (RLRL) therapy for myopia control. METHODS: We conducted a mediation analysis within a multicenter, randomized controlled trial. A total of 300 myopic children were included in this analysis. Participants in RLRL group wore single-vision spectacles (SVSs) and received red-light therapy twice daily for 12 months. The control group wore SVSs only, without any additional myopia-control intervention. Axial length (AL), spherical equivalent refraction (SER), SFCT and total refractive difference value (TRDV) were measured at baseline and at follow-up visits over 12 months. RESULTS: After 12 months, RLRL therapy significantly attenuated axial length and myopic shift in spherical equivalence compared with controls, accompanied by sustained increases in choroidal thickness and reductions in peripheral hyperopic defocus. Mediation analysis revealed that changes in choroidal thickness and peripheral refraction accounted for 24.83% and 6.79%, respectively, of the effect on axial length inhibition, and 28.79% and 5.97% of the effect on spherical equivalent control. The remaining effects were attributable to the direct impact of red-light (68.39% for axial length and 65.24% for spherical equivalence). Notably, choroidal thickening emerged as the predominant mediator within the first three months. CONCLUSIONS: RLRL therapy exerted a predominantly direct effect on myopia control, while changes in choroidal thickness and peripheral defocus partially mediated its effectiveness. TRIAL REGISTRATION: This trial was registered at the Chinese Clinical Trial Registry on January 30, 2021, with trial registration number: ChiCTR2100042836. https://www.chictr.org.cn/showprojEN.html?proj=120971 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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