Effects of time-restricted eating without caloric restriction on blood pressure and cardiometabolic profile in non-diabetic adults: a systematic review and meta-analysis of randomized controlled trials
Yi X, Yan J, Daut UN, Abas R, Raja Muhammad Rooshdi RAW, Yang C, Liu C
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
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- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-19 · Front Nutr · vol. 12 · pág. 1631477
- Editorial
- Frontiers Media
- Citado
- 1 cita · más que el 44% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Blood Pressure and Hypertension Studies
- Palabras clave
- time-restricted eating, caloric restriction, blood pressure, cardiometabolic profile, insulin resistance, fasting insulin, fasting blood glucose, heart rate, body mass index, non-diabetic adults, eating window, hypertension, obesity, metabolic syndrome, HOMA-IR, systolic blood pressure, diastolic blood pressure, weight loss, non-pharmacological treatment
7 autores
- Xin Yi🇲🇾🇨🇳 · autor de correspondenciaUniversiti Putra Malaysia; North China University of Science and Technology Affiliated Hospital
- Jie Yan🇨🇳North China University of Science and Technology Affiliated Hospital
- Ummi Nadira Daut🇲🇾Universiti Putra Malaysia
- Razif Abas🇲🇾Universiti Putra Malaysia
- Raja Abdul Wafy Raja Muhammad Rooshdi🇲🇾Universiti Putra Malaysia
- Chongshuang Yang
- Canzhang Liu🇨🇳North China University of Science and Technology Affiliated Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To systematically evaluate the effect of time-restricted eating (TRE) without caloric restriction (CR) on blood pressure (BP) and cardiometabolic profile in non-diabetic adults.
Methods
A comprehensive search of electronic databases identified 978 potentially relevant studies, of which 11 randomized controlled trials involving 653 participants were included in this meta-analysis. All included studies compared time-restricted eating (TRE; 6-10-h daily eating windows) without CR to unrestricted feeding controls. Outcomes assessed included systolic BP (SBP), diastolic BP (DBP), heart rate (HR), fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), and body mass index (BMI). Weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated using random-effects models.
Results
TRE without CR significantly reduced SBP (WMD = -1.79 mmHg, 95% CI: -3.30 to -0.27, p = 0.02), DBP (WMD = -1.75 mmHg, 95% CI: -3.07 to -0.43, p = 0.01), and HR (WMD = -2.19 bpm, 95% CI: -4.01 to -0.36, p = 0.02). Subgroup analyses showed greater BP reductions in participants with elevated baseline SBP or DBP. TRE also led to significant improvements in metabolic parameters, including reductions in FBG (WMD = -2.65 mg/dL, 95% CI: -3.92 to -1.39, p p = 0.0001), HOMA-IR (WMD = -0.58, 95% CI: -0.81 to -0.35, p 2, 95% CI: -2.98 to -0.20, p = 0.03). Heterogeneity across outcomes was negligible to moderate.
Conclusion
TRE without CR can significantly reduce BP and improve glucose metabolism in non-diabetic adults, particularly in those with pre-existing high BP or high FBG or High FINS. However, TRE does not appear to exert meaningful effects on lipid profiles in the absence of CR, indicating that its cardiometabolic benefits may be selective rather than comprehensive. These findings support the potential of TRE as a non-pharmacological intervention for cardiometabolic health, particularly in populations with elevated baseline risk markers.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO, identifier CRD420251052403.
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