Cereal beta-glucan and cardiovascular disease risk reduction in overweight and obese populations: a systematic review and meta-analysis of lipid, blood pressure, and anthropometric parameters
Zheng R, Zhang H, Hua H, Zhang Y, Jin C, Zhou Y, Shi X, Zhu L, Zhu L
Food & function · 1 cita
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Key Technology Research and Development Program of Shandong
- Subvenciones
- Key Technology Research and Development Program of Shandong (2024CXGC010918)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-11-25 · Food Funct · vol. 17 · número 1 · págs. 70–88
- Editorial
- Royal Society of Chemistry
- Citado
- 7 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 111 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Diabetes, Cardiovascular Risks, and Lipoproteins · Nutritional Studies and Diet
- Palabras clave
- cereal β-glucan, oat β-glucan, cardiovascular risk, overweight, obesity, total cholesterol, LDL cholesterol, systolic blood pressure, triglycerides, HDL cholesterol, body mass index, dietary fiber
- MeSH
- humans, cardiovascular diseases, obesity, beta-glucans, lipids, body mass index, blood pressure, adult, middle aged, male, overweight, edible grain
8 autores
- Ruihao Zheng🇨🇳Jiangnan University; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
- Hui Zhang🇨🇳Jiangnan University; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
- Hongying Hua
- Yan Zhang
- Chengming Jin🇨🇳Jiangnan University; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
- Yijun Zhou🇨🇳Jiangnan University; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
- Xiaowei Shi🇨🇳Jiangnan University; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
- Ling Zhu🇨🇳Jiangnan University; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
Resumen
El texto original del estudio, en el idioma en que se publicó.
Obesity-related dyslipidemia and hypertension are the key drivers of global cardiovascular disease (CVD) mortality. Although the lipid-lowering capacity of beta-glucan has been demonstrated in the general population, evidence regarding its effects on dyslipidemia and hypertension in overweight and obese populations remains limited. As of April 23, 2025, we searched nine databases. Two reviewers independently conducted study screening, data extraction, and bias assessment. We assessed the effects of cereal beta-glucan (CBG) on lipids, blood pressure, and anthropometric parameters in individuals with a body mass index (BMI) ≥25 kg m-2. This article included 49 eligible studies involving 3854 subjects. Pooled analyses showed that CBG significantly reduced total cholesterol [TC, -0.24 mmol L-1 (-0.31, -0.17), P -1 (-0.25, -0.13), P -1 and durations ≥6 weeks. Oat beta-glucan also lowered the systolic blood pressure [SBP, -1.38 mmHg (-2.66, -0.09), P = 0.036]. No effects were observed for triglycerides, high-density lipoprotein cholesterol, diastolic blood pressure, or body weight. BMI results were conflicting owing to publication bias. In conclusion, CBG reduces TC and LDL-C, and oat beta-glucan may modestly lower SBP in overweight and obese populations. These results support evidence-based recommendations for integrating CBG into CVD prevention strategies.
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