Psyllium supplementation and lipid profiles: systematic review and dose-response meta-analysis of randomized controlled trials
Gholami Z, Paknahad Z
Genes & nutrition · 1 cita
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Isfahan University of Medical Sciences
- Universidad u hospital
- Student Research Committee, Tabriz University of Medical Sciences
- Subvenciones
- Isfahan University of Medical Sciences (140206)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-12-01 · Genes Nutr · vol. 20 · número 1 · pág. 27
- Editorial
- BioMed Central
- Citado
- 3 citas · más que el 62% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Food composition and properties · Lipoproteins and Cardiovascular Health · Natural Products and Biological Research
- Palabras clave
- lipid profile, LDL cholesterol, HDL cholesterol, triglycerides, total cholesterol, dose-response relationship, dietary fiber, hypercholesterolemia, dyslipidemia
2 autores
- Zeinab Gholami🇮🇷Isfahan University of Medical Sciences
- Zamzam Paknahad🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Some studies indicate that psyllium supplementation may change lipid profile levels. This study assessed the impact of psyllium consumption on lipid profile (Low-Density Lipoprotein Cholesterol, Triglyceride, High-Density Lipoprotein Cholesterol, and cholesterol).
Main text
We started searching articles using Scopus, Institute for Scientific Information Web of Science, and PubMed to identify eligible publications from March 15, 2022 to August 2, 2025. The effect of psyllium on lipid profiles in adults was evaluated through Randomized Controlled Trials. We calculated Weighted Mean Differences with 95% Confidence Intervals using a random effects model. In this study, 41 Randomized Controlled Trials articles and 2049 participants were included. Psyllium showed a significant decrease in Low-Density Lipoprotein Cholesterol and total Cholesterol, a nonsignificant reduction in Triglyceride, and an insignificantly increase in High-Density Lipoprotein Cholesterol; cholesterol: (Weighted Mean Differences: -9.05; 95% Confidence Intervals: -13.71, -4.40; p-value 0.05), Triglyceride: (Weighted Mean Differences: -5.29; 95% Confidence Intervals: -12.14, 1.54; p-value > 0.05), and Low-Density Lipoprotein Cholesterol: (Weighted Mean Differences: -8.55; 95% Confidence Intervals: -12.92, -4.19; p < 0.001). Considerable heterogeneity was found for cholesterol: (I-squared index = 89.30%, p-value < 0.001), High-Density Lipoprotein Cholesterol: ( I-squared index = 77.96%, p-value < 0.001), Low-Density Lipoprotein Cholesterol: (I-squared index = 88.46%, p-value < 0.001); and Triglyceride: (I-squared index = 83.25%, p-value < 0.001) and duration and dosage of psyllium had a nonsignificant linear influence on lipid profiles.
Conclusion
Results showed that psyllium can significantly decrease Low-Density Lipoprotein Cholesterol and total cholesterol, can insignificantly decrease triglyceride, and can insignificantly increase High-Density Lipoprotein Cholesterol following psyllium consumption.
Registration
The study was approved by the Medical Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.
Research
REC.1402.017, Grant number: 140206). This research was registered in the PROSPERO system (CRD42023402987).
Clinical trial number
Not applicable.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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