Effect of Dietary Nitrate Intake on Fatigue Resistance Following Ischemia-Induced Microvascular Dysfunction in Males and Females
Souza Filho CA, Ramos OJF, Soares RN, Alvares TDS
The Journal of nutrition · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (309262/2023-2); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/210.071/2022); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/200.546/2023)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2025-12-08 · J Nutr · vol. 156 · número 2 · pág. 101263
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 43% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses
- Palabras clave
- dietary nitrate, beetroot juice, skeletal muscle fatigue, microvascular dysfunction, ischemia, sex differences, nitric oxide bioavailability, forearm ischemia, tissue oxygen saturation, nitrite/nitrate
- MeSH
- muscle, skeletal, microcirculation, humans, beta vulgaris, ischemia, nitrates, nitrites, cross-over studies, double-blind method, muscle fatigue, dietary supplements, adult, female, male, microvessels, young adult, fruit and vegetable juices
4 autores
- Carlos Alberto de Souza Filho🇧🇷Universidade Federal do Rio de Janeiro
- Olavo João Frederico Ramos🇧🇷Universidade Federal do Rio de Janeiro
- Rogério N. Soares🇺🇸 · autor de correspondenciaWayne State University
- Thiago Silveira Álvares🇧🇷 · autor de correspondenciaUniversidade Federal do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Skeletal muscle fatigue reflects the interaction of metabolic demand, contractile efficiency, and oxygen delivery, processes highly dependent on microvascular function. Prolonged ischemia induces transient microvascular dysfunction that can impair fatigue resistance. Dietary nitrate, abundant in beetroot juice, enhances nitric oxide bioavailability and vascular function, but whether it mitigates ischemia-induced decrements in microvascular reactivity and fatigue resistance remains unclear.
Objectives
To determine whether a single oral dose of nitrate-rich beetroot juice (NR-BJ) protects against prolonged ischemia-induced impairments in microvascular function and fatigue resistance in a sex-dependent manner.
Methods
Sixteen healthy adults (8 males, 8 females; 20-40 y) completed a randomized, double-blind, crossover trial with NR-BJ (∼10 mmol nitrate) or nitrate-depleted beetroot juice (ND-BJ, ∼0.34 mmol nitrate). Two hours postingestion, participants underwent 20 min of forearm arterial occlusion to induce microvascular dysfunction. Microvascular reactivity was assessed by near-infrared spectroscopy (tissue oxygen saturation resaturation slope), and fatigue resistance was determined during 50 maximal isokinetic wrist flexion-extension contractions. Serum nitrate and nitrite were measured by high-performance liquid chromatography.
Results
Circulating nitrate and nitrite increased significantly after NR-BJ in both males and females. Prolonged ischemia reduced the tissue oxygen saturation resaturation slope in both sexes under the ND-BJ condition. NR-BJ attenuated this decline in females but not in males. In males, ischemia reduced total work and early-phase work (the first one-third of repetitions) under ND-BJ, effects that were prevented by NR-BJ. Fatigue resistance was preserved in females across conditions.
Conclusions
Acute dietary nitrate supplementation preserves fatigue resistance in males despite persistent microvascular dysfunction, whereas in females it attenuates ischemia-induced microvascular impairment without affecting fatigue resistance. These findings support sex-specific protective effects of dietary nitrate against transient vascular stress.
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