Extra Virgin Olive Oil (EVOO) Improves Vascular Endothelial Function and Hemodynamic Parameters in Patients with Hyperlipidemia: A Post Hoc Analysis of a Randomized Controlled Trial
Kourek C, Makaris E, Benetou V, Magiatis P, Zouganeli V, Dimopoulos S, Georgiopoulos G, Briasoulis A, Paraskevaidis I, Melliou E, Orfanos P
Nutrients · 1 cita
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-21 · Nutrients · vol. 17 · número 23 · pág. 3650
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 1 cita · más que el 49% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Edible Oils Quality and Analysis · Cardiovascular Health and Disease Prevention · Fatty Acid Research and Health
- Palabras clave
- extra virgin olive oil, hyperlipidemia, endothelial function, hemodynamic parameters, polyphenols, dose comparison, blood pressure, heart rate, reperfusion rate
- MeSH
- endothelium, vascular, humans, heart rate, adult, aged, middle aged, female, male, hyperlipidemias, hemodynamics, polyphenols, olive oil
11 autores
- Christos Kourek🇬🇷 · autor de correspondenciaNational and Kapodistrian University of Athens; NIMTS Hospital
- Emmanouil Makaris
- Vassiliki Benetou🇬🇷National and Kapodistrian University of Athens
- Prokopios Magiatis🇬🇷National and Kapodistrian University of Athens
- Virginia Zouganeli🇬🇷National and Kapodistrian University of Athens
- Stavros K. Dimopoulos🇬🇷Onassis Cardiac Surgery Center
- Georgios A. Georgiopoulos🇬🇷National and Kapodistrian University of Athens
- Αlexandros Briasoulis🇬🇷National and Kapodistrian University of Athens
- IOANNIS A. PARASKEVAIDIS🇬🇷National and Kapodistrian University of Athens
- Eleni Melliou🇬🇷National and Kapodistrian University of Athens
- Philippos Orfanos🇬🇷National and Kapodistrian University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Extra virgin olive oil (EVOO) exhibits potent antioxidant and anti-inflammatory properties. Recent findings from our Institute indicate that its bioactive compounds enhance lipid metabolism, suggesting EVOO as a promising nutritional intervention for hyperlipidemic patients. This clinical study aimed to evaluate the effects of EVOO consumption on vascular endothelial function and hemodynamic parameters in hyperlipidemic individuals, while comparing two EVOO types differing in polyphenol content and dosage. Methods: This post hoc analysis included 70 participants: 50 patients with hyperlipidemia and 20 healthy controls. All participants consumed EVOO daily for four weeks. Hyperlipidemic patients were randomized into two subgroups: one receiving high-phenolic EVOO at a low dose and another receiving low-phenolic EVOO at a high dose, ensuring equivalent total polyphenol intake. Vascular endothelial function, assessed via near-infrared spectroscopy (NIRS), served as the primary endpoint, while arterial blood pressure and heart rate were secondary endpoints. Statistical analyses employed mixed linear models. Results: Hyperlipidemic patients exhibited significant improvements in endothelial function, with increased reperfusion rate (p = 0.010) and oxygen consumption rate (p p = 0.004) and hyperemia recovery time (p p = 0.007) and heart rate (p = 0.004) decreased significantly. Among subgroups, high-phenolic EVOO at lower doses was more effective in reducing systolic blood pressure (p = 0.049) and improving reperfusion rate (p = 0.049). Conclusions: EVOO consumption improved endothelial function and hemodynamic parameters in hyperlipidemic patients, with high-phenolic EVOO demonstrating superior vascular benefits at lower doses.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.