Financiado en parte por U.S. Highbush Blueberry Council, USHBC
Effects of Blueberry Supplementation on Depression and Anxiety Symptoms in a Rural Louisiana Population
Venable KE, Kelley DP, Jeansonne A, Beyl R, O'Bryan S, Vatsavayi V, Jones S, Lee CC, Francis J
Nutrients · 2 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Deafness and Other Communication Disorders
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- NIH HHS
- Gobierno
- NIDCD NIH HHS
- Grupo de la industria
- USHBC
- Gobierno
- NINDS NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute on Deafness and Other Communication Disorders (R01 DC019348); National Institute of Neurological Disorders and Stroke (R03NS122892); National Institutes of Health (R01 DC 019348); National Institutes of Health (R01 HL 147133)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-27 · Nutrients · vol. 17 · número 23 · pág. 3720
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 3 citas · más que el 82% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Medicinal Plant Extracts Effects · Tryptophan and brain disorders
- Palabras clave
- depression, anxiety, nutraceuticals, anthocyanins, polyphenols, major depressive disorder, generalized anxiety disorder, inflammatory cytokines, C-reactive protein, plasma metabolomics, rural health, mood
- MeSH
- humans, fruit, cytokines, pilot projects, cross-over studies, double-blind method, depression, anxiety, anxiety disorders, dietary supplements, adult, middle aged, rural population, female, male, blueberry plants, major depressive disorder
9 autores
- Katy E. Venable🇺🇸Louisiana State University
- D. Parker Kelley🇺🇸Louisiana State University
- Alec Jeansonne
- Robbie A. Beyl🇺🇸Pennington Biomedical Research Center; Louisiana State University
- Samia M. O’Bryan🇺🇸Louisiana State University
- Venugopal Vatsavayi🇺🇸Baton Rouge Clinic
- Samuel Jones
- Charles C. Lee🇺🇸 · autor de correspondenciaLouisiana State University
- Joseph Francis🇺🇸Louisiana State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Blueberries are an important nutraceutical due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins. These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with depression and anxiety. In this regard, there is an unmet need for novel, effective, and accessible treatments for these conditions, particularly in rural communities, where specialized health care is often limited. Methods: Therefore, we conducted a double-blind, randomized pilot study in a rural population to assess whether daily blueberry supplementation affected symptoms of anxiety and depression. We employed a crossover design to test the effects of 12 weeks daily ingestion of 24 g of whole freeze-dried blueberry powder versus placebo on symptoms of depression and anxiety in those diagnosed with a depressive or anxiety disorder including major depressive disorder (MDD) and generalized anxiety disorder (GAD). We collected behavioral data (HDRS, GAD-7, MDI) at baseline, mid-, and post-treatment timepoints. We collected blood, serum, plasma, and behavioral data (HDRS, GAD-7, MDI) at baseline, mid-, and post-treatment timepoints. We measured inflammatory cytokines IL-1β, IL-6, TNF-α, IFN-γ, and IL-10 in serum, CRP in whole blood, and performed global metabolomics in plasma. Results: Blueberries significantly reduced symptoms of depression and anxiety compared to placebo. CRP and inflammatory cytokine levels were unaffected. Our global metabolomic measures suggested that different metabolites were differentially affected at the middle and post-intervention timepoints in the study. Conclusions: Overall, this study found potential improvements in symptoms of depression and anxiety following daily blueberry supplementation, although the biochemical mechanisms underlying these behavioral improvements remain unresolved.
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