Effectiveness and metabolic impacts of restricting the consumption of ultra-processed foods in individuals with obesity submitted to energy restriction: a randomized clinical trial
Macena ML, Pereira MR, Silva DR, Silva-Júnior AE, Oliveira ADS, Santos JVL, Paula DTC, Galdino-Silva MB, Almeida KMM, Ferro DC, Carvalho GCO, Rocha MVC, Lopes NGS, Carnaúba RTL, Carvalho SAM, Clemente APG, Bádue GS, Melo ISV, Barros-Neto JA, Florêncio TMMT, Martins VJB, Bueno NB
Nutrition, metabolism, and cardiovascular diseases : NMCD · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Alagoas
- Gobierno
- Ministério da Ciência, Tecnologia e Inovação
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidad u hospital
- Universidade Federal de Alagoas
- Gobierno
- National Council for Scientific and Technological Development
- Gobierno
- Coordination for the improvement of Higher Education Personnel
- Gobierno
- Foundation for Research Support of Alagoas State
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de Alagoas (002/2022); Conselho Nacional de Desenvolvimento Científico e Tecnológico (409166/2021-9); Universidade Federal de Alagoas (001/2024); Conselho Nacional de Desenvolvimento Científico e Tecnológico (311401/2022–8); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.679721/2022\u201300); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.824262/2023\u201300); Conselho Nacional de Desenvolvimento Científico e Tecnológico (140168/2025-7)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2025-10-30 · Nutr Metab Cardiovasc Dis · vol. 36 · número 5 · pág. 104426
- Editorial
- Elsevier BV
- Citado
- 6 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Dietary Effects on Health · Obesity, Physical Activity, Diet
- Palabras clave
- ultra-processed foods, obesity, caloric restriction, weight loss, NOVA classification, dietary intervention, body composition, metabolic effects, dietary adherence
- MeSH
- humans, obesity, weight loss, treatment outcome, caloric restriction, diet, reducing, body composition, energy metabolism, energy intake, time factors, adult, middle aged, female, male, fast foods, food, processed
22 autores
- Mateus de Lima Macêna🇧🇷Universidade Federal de Alagoas; Universidade Federal de São Paulo
- Micnéias Róberth Pereira🇧🇷Universidade Federal de Alagoas
- Dafiny Rodrigues Silva🇧🇷Universidade Federal de Alagoas; Universidade Federal de São Paulo
- André Eduardo da Silva Júnior🇧🇷Universidade Federal de Alagoas; Universidade Federal de São Paulo
- Ana Debora Santos de Oliveira🇧🇷Universidade Federal de Alagoas
- João Victor Laurindo dos Santos🇧🇷Universidade Federal de Alagoas
- Déborah Tenório da Costa Paula🇧🇷Universidade Federal de Alagoas
- Maria Bárbara Galdino-Silva🇧🇷Universidade Federal de Alagoas
- Karine Maria Moreira Almeida🇧🇷Universidade Federal de Alagoas
- Débora Cavalcante Ferro🇧🇷Universidade Federal de Alagoas
- Guilherme César Oliveira de Carvalho🇧🇷Universidade Federal de Alagoas
- Marianna Victória Cerqueira Rocha🇧🇷Universidade Federal de Alagoas
- Natália Gomes da Silva Lopes🇧🇷Universidade Federal de Alagoas
- Rodrigo Tenório Lins Carnaúba🇧🇷Universidade Federal de Alagoas
- Samyra A.M. Carvalho🇧🇷Universidade Federal de Alagoas
- Ana Paula Grotti Clemente🇧🇷Universidade Federal de Alagoas
- Gabriel Soares Bádue🇧🇷Universidade Federal de Alagoas
- Ingrid Sofia Vieira de Melo🇧🇷Instituto Federal de Educação, Ciência e Tecnologia de Alagoas
- João Araújo Barros-Neto🇧🇷Universidade Federal de Alagoas
- Telma Maria de Menezes Toledo Florêncio🇧🇷Universidade Federal de Alagoas
- Vinícius José Baccin Martins🇧🇷Universidade Federal da Paraíba
- Nassib Bezerra Bueno🇧🇷 · autor de correspondenciaUniversidade Federal de Alagoas; Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
To evaluate the effectiveness and metabolic effects of restricting UPF consumption in individuals with obesity undergoing energy restriction.
Methods and results
Randomized, parallel clinical trial, lasting 12 months. Participants were randomly allocated into two groups: (a) generic energy restriction (ER-G) and (b) energy restriction associated with UPF restriction (ER-UPF). Energy requirements were determined using calorimetry and accelerometry data. Anthropometric, dietary, body composition, metabolic, and biochemical data were collected. 148 individuals were included. The baseline intake of UPF was 21.16 [18.42; 23.90]% in the ER-UPF group and 23.70 [20.92; 26.48]% in the ER-G group, and, at 12 months, decreased to 13.86 % in the ER-UPF and to 20.02 % in the ER-G (p = 0.08). The ER-UPF group reduced the NOVA-UPF Score (from 2.74 [2.28; 3.20] to 1.86 [1.18; 2.53] at 12 months) compared to the ER-G (from 2.62 [2.15; 3.09] to 2.47 [1.76; 3.17]; p = 0.03). The monthly bodyweight data analysis showed that the ER-UPF group lost more weight compared to the ER-G group (final values: 82.9 [79.6; 86.2] kg vs. 86.3 [83.0; 89.7] kg; p = 0.01). Despite these findings, no changes were observed in the other outcomes.
Conclusion
The proposed intervention resulted in significantly smaller decreases in UPF intake than expected and induced only a statistically, but non-clinically significant, greater weight loss compared to the ER-G. These findings may be partially explained by the fact that individuals had low UPF intake in the baseline. Future studies should focus on populations with higher basal UPF intake.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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