Effects of low-carbohydrate time-restricted eating, with or without sprint interval training, on resting cardiac biomarkers in young adults: a sex-stratified randomized controlled trial
Zhou Y, Lei OK, Shi X, Zhang H, George K, Nie J, Shi Q, Kong Z
European journal of applied physiology · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Macao Polytechnic University
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-12-19 · Eur J Appl Physiol · vol. 126 · número 5 · págs. 2633–2645
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 36% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Cardiovascular and exercise physiology · Diet and metabolism studies
- Palabras clave
- sprint interval training, NT-proBNP, cardiac troponin T, cardiac biomarkers, sex differences, young adults, fat loss, VO2max, cardiometabolic health
- MeSH
- humans, natriuretic peptide, brain, peptide fragments, troponin t, body composition, adult, female, male, diet, carbohydrate-restricted, young adult, biomarkers, high-intensity interval training, intermittent fasting
8 autores
- Yingqi Zhou🇲🇴Macao Polytechnic University
- On Kei Lei🇲🇴University of Macau
- Xueying Shi🇨🇳🇲🇴Zhumadian Preschool Education College; Macao Polytechnic University
- Haifeng Zhang🇨🇳University of Health and Rehabilitation Sciences
- Keith George🇬🇧Liverpool John Moores University
- Jinlei Nie🇲🇴Macao Polytechnic University
- Qingde Shi🇲🇴Macao Polytechnic University
- Zhaowei Kong🇲🇴 · autor de correspondenciaUniversity of Macau
Resumen
El texto original del estudio, en el idioma en que se publicó.
PURPOSE: Low-carbohydrate time-restricted eating (LCTR) and sprint interval training (SIT) independently improve cardiometabolic health, but their combined effects on cardiac-specific biomarkers remain unknown. We investigated whether LCTR, with or without SIT, affects N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) concentrations in young adults. METHODS: Sixty-one young adults (31 males, 30 females) were randomized to a 4-week program of LCTR alone or LCTR + SIT. All participants consumed ≤ 10% of energy from carbohydrates within an 8-hour daily window. LCTR + SIT groups additionally performed 5 weekly sessions of 10 × 6-second sprints with 9-second recovery periods. Body composition, V̇O₂max, and NT-proBNP and cTnT were assessed pre- and post-intervention. Data were analyzed using three-way mixed ANOVA with intervention (LCTR vs. LCTR + SIT) and sex as between-subjects factors, and time as within-subjects factor. RESULTS: Body fat decreased across all groups (range -1.2 to -2.6 kg, P < 0.05), with no significant between-group differences. Significant intervention × time interaction was observed for V̇O₂max (P = 0.003), whereas NT-proBNP showed a significant intervention × sex × time interaction (P = 0.016). Post-hoc analyses revealed that only females in the LCTR + SIT group demonstrated a significant improvement in V̇O2max (+ 17.1%, P = 0.014) and a reduction in NT-proBNP (-48%, P = 0.0005). Resting cTnT levels did not change in any group, with most values at or below detection limits. CONCLUSION: Brief LCTR, with or without SIT, reduced body fat in both sexes. Only females in the LCTR + SIT group demonstrated reduced resting NT-proBNP. Reasons for, and implications of, this rapid and sex-mediated adaptation in NT-proBNP are worthy of further study.
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