Opposing Effects of Dietary Nitrate on Muscle Contractile Function in Fast and Slow Human Muscles
Zoughaib WS, Fry MJ, Singhal A, Hoffman RL, Coggan AR
Medicine and science in sports and exercise · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- NHLBI NIH HHS
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-12-23 · Med Sci Sports Exerc · vol. 58 · número 5 · págs. 1012–1020
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 0 citas · más que el 42% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Muscle Physiology and Disorders
- Palabras clave
- dietary nitrate, nitric oxide bioavailability, muscle contractility, post-activation potentiation, fast-twitch muscle, slow-twitch muscle, triceps brachii, triceps surae, calcium sensitivity, myosin regulatory light chain phosphorylation, beetroot juice, neuromuscular electrical stimulation
- MeSH
- muscle fibers, fast-twitch, muscle fibers, slow-twitch, muscle, skeletal, humans, beta vulgaris, nitrates, cross-over studies, double-blind method, electric stimulation, muscle contraction, torque, dietary supplements, adult, male, young adult, fruit and vegetable juices
5 autores
- William S. Zoughaib🇺🇸Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Madison J. Fry🇺🇸Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Ahaan Singhal🇺🇸Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Richard Leigh Hoffman🇺🇸Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Andrew R. Coggan🇺🇸 · autor de correspondenciaIndiana University Indianapolis; Indiana University – Purdue University Indianapolis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Increasing nitric oxide bioavailability via nitrate (NO 3- ) ingestion enhances muscle contractility, which may be due to phosphorylation of the regulatory light chain of myosin. If so, there should be an interaction between NO 3- supplementation and post activation twitch potentiation, which acts via the same pathway.
Methods
A double-blind, placebo-controlled, randomized crossover study was conducted to determine the influence of dietary NO 3- on the contractile properties of the triceps brachii (60%-70% fast-twitch, or type II) and triceps surae (60%-70% slow-twitch, or type I) muscles of healthy young men ( n = 14). Participants were studied after acute ingestion of 2.2 mL/kg of beetroot juice either containing or lacking 200 µmol/kg of NO 3- , with neuromuscular electrical stimulation used to determine muscle function.
Results
NO 3- supplementation did not alter unpotentiated or potentiated peak twitch torque or the maximal rates of torque development or relaxation in either muscle group. On the other hand, NO 3- ingestion resulted in significant changes in the torque-frequency relationship of both the triceps brachii ( P = 0.019) and the triceps surae ( P < 0.001). This was due to a leftward shift of this sigmoidal relationship in the triceps brachii, but a rightward shift in the triceps surae.
Conclusions
We conclude that dietary NO 3- has opposing effects on the contractile properties of fast and slow human muscles, which could be due to differential changes in Ca 2+ sensitivity. However, potentiation was unaltered, suggesting that this occurs independently of changes in regulatory light chain phosphorylation. Additional research will be required to determine the underlying biochemical mechanisms.
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