Creatine supplementation and resistance training: a comparison between novice and experienced lifters - a systematic review and dose-response meta-analysis
Ashtary-Larky D, Mohammadi S, Hajizadeh L, Mousavi SAH, Forbes SC, Candow DG, Antonio J
Journal of the International Society of Sports Nutrition · 4 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-09-30 · J Int Soc Sports Nutr · vol. 22 · número sup1 · pág. 2586523
- Editorial
- Springer Science+Business Media
- Citado
- 4 citas · más que el 65% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 114 trabajos
- Acceso
- Acceso abierto (revista) · OTHER-OA
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Cardiovascular and exercise physiology
- Palabras clave
- Resistance training, Sports medicine, Clinical nutrition, Creatine, Physical activity, Anthropometry
- MeSH
- humans, creatine, body mass index, body composition, dose-response relationship, drug, weight lifting, dietary supplements, resistance training
7 autores
- Damoon Ashtary‐Larky🇮🇷 · autor de correspondenciaAhvaz Jundishapur University of Medical Sciences
- Shooka Mohammadi🇲🇾University of Malaya
- Leila Hajizadeh🇮🇷Islamic Azad University, Marvdasht
- Seyed Amir Hossein Mousavi🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Scott C. Forbes🇨🇦Brandon University
- Darren Glenn Candow🇨🇦University of Regina
- Jose Antonio🇺🇸 · autor de correspondenciaSoutheastern University; Nova Southeastern University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Creatine (Cr) supplementation is well established for enhancing fat-free mass (FFM) when combined with resistance training (RT). However, the influence of prior training experience on supplementation efficacy remains unknown.
Objective
This systematic review and dose-response meta-analysis of controlled trials evaluated the effects of Cr supplementation combined with RT on body composition, with particular emphasis on the differences between trained (experienced) and untrained (novice) individuals.
Methods
A systematic search of major databases was conducted to identify controlled trials published until March 2025. The effects of Cr supplementation on body mass, body mass index (BMI), FFM, fat mass (FM), and body fat percentage (BFP) were examined using random-effects meta-analysis.
Results
A pooled analysis of 61 trials revealed that Cr supplementation significantly increased FFM (weighted mean difference [WMD]: 1.39 kg; 95% confidence intereval (CI): 1.07,1.70; p p < 0.001) without significant effects on FM, BMI, and BFP. Trained individuals exhibited greater, though non-significant, gains in FFM (1.82 vs. 1.23 kg) compared with untrained participants, despite similar increases in total body mass. Dose-response analyses identified significant relationships between Cr dose and changes in body mass and BMI. Furthermore, supplementation duration was associated with changes in BFP and body mass.
Conclusion
Both novice and experienced lifters gained FFM with Cr supplementation compared to placebo. The increase in FFM was approximately 0.6 kg (≈50%) greater in experienced participants; however, this between-group difference was not statistically significant.
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