Financiado en parte por United Soybean Board, Soy Nutrition Institute
Feasibility Study of Soybean Oil-Fortified Foods to Alter Blood Content of Linoleic Acid and Body Weight: A Randomized Double-Masked Placebo-Controlled Crossover Trial
Cole RM, Colombo E, Angelotti A, Sparagna GC, Choriego RE, Jimenez-Flores R, Ni A, Belury MA
The Journal of nutrition · 2 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- United Soybean Board
- Grupo de la industria
- Soy Nutrition Institute
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Subvenciones
- United Soybean Board (2411-108-0101); National Center for Advancing Translational Sciences (336 UM1TR004548)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2025-12-27 · J Nutr · vol. 156 · número 2 · pág. 101288
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 70% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Crossover study, Linoleic acid, Body weight, Conjugated linoleic acid, Randomized controlled trial, Safflower oil, Food intake
- MeSH
- humans, body weight, soybean oil, linoleic acid, feasibility studies, pilot projects, cross-over studies, double-blind method, food, fortified, adult, aged, middle aged, female, male, biomarkers, palm oil
8 autores
- Rachel M. Cole🇺🇸The Ohio State University
- Eric Colombo🇺🇸The Ohio State University Wexner Medical Center
- Austin Angelotti🇺🇸Penn State Milton S. Hershey Medical Center
- Genevieve C. Sparagna🇺🇸University of Colorado Anschutz
- Rolando E Choriego🇺🇸The Ohio State University
- Rafael Jimenez-Flores🇺🇸The Ohio State University
- Andy Ni🇺🇸The Ohio State University
- Martha Ann Belury🇺🇸 · autor de correspondenciaThe Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Linoleic acid biomarkers are associated with positive health outcomes including lower risk of diabetes and cardiovascular disease. The effect of consuming linoleate-fortified foods (compared with palm oil-fortified foods) in a randomized controlled, double-masked crossover study to change linoleic acid biomarkers without changing bodyweight is unknown.
Objectives
The aim of this study was to determine the effect of delivering soybean and palm oils through foods on the linoleic acid content of blood fractions and body weight in adults.
Methods
In this crossover pilot study, 4 male and 6 female adults, ages 25-76 y and body mass index from 26 to 41 kg/m2, were randomly assigned to consume: 30 g of soybean and palm oil delivered in 3 study foods/d for 4 wk separated by a 2-wk washout period. Bodyweight, fatty acid profile of plasma, erythrocytes, peripheral blood mononuclear cells (PBMC), and dried blood spots, and PBMC cardiolipin were measured before and after each intervention period. Dietary intake was assessed using 24-h recalls. The outcomes were analyzed using the Wilcoxon Signed Rank Test.
Results
After 4 wk of consuming 3 foods/d, plasma linoleic acid decreased during the palm oil intervention (-1.60, P = 0.04), whereas it tended to increase in plasma (2.35, P = 0.07) and erythrocytes (1.09, P = 0.05) during the soybean oil intervention. The percentage of PBMC tetralinoleoyl cardiolipin marginally increased during the soybean oil intervention (2.31, P = 0.05) but did not change during the palm oil intervention. There was no difference in energy intake between the 2 interventions (P = 0.65) and no change in bodyweight during either intervention (P > 0.40).
Conclusions
Foods can be used to deliver 30 g/d of dietary oil for 4 wk to impact linoleic acid biomarkers without incurring body weight changes. These foods are useful for future randomized controlled double-masked clinical trials assessing the impact of dietary oils on energy metabolism. The study was registered at clinicaltrials.gov as NCT04975763 (https://clinicaltrials.gov/study/NCT04975763).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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