Systematic review and meta-analysis on the effect of olive oil in the treatment of periodontal diseases
López-Valverde N, López-Valverde A, Blanco Rueda JA
Frontiers in oral health · 1 cita
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-12-18 · Front Oral Health · vol. 6 · pág. 1735845
- Editorial
- Frontiers Media
- Citado
- 1 cita · más que el 50% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Medical and Biological Ozone Research · Oral microbiology and periodontitis research · Periodontal Regeneration and Treatments
- Palabras clave
- olive oil, ozonated olive oil, periodontitis, gingivitis, periodontal treatment, natural products, anti-inflammatory activity, antimicrobial activity, bleeding on probing, clinical attachment level, probing depth, plaque index, gingival index, bleeding index
3 autores
- Nansi López-Valverde🇪🇸Universidad de Salamanca; Instituto de Investigación Biomédica de Salamanca
- Antonio López‐Valverde🇪🇸 · autor de correspondenciaUniversidad de Salamanca; Instituto de Investigación Biomédica de Salamanca
- José Antonio Blanco Rueda🇪🇸Universidad de Salamanca; Instituto de Investigación Biomédica de Salamanca
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Periodontal diseases, which are highly inflammatory in nature, are very common throughout the world. In recent years, natural products have gained special attention as a complement to conventional therapy, and olive oil/ozonated olive oil (OLO/OzOLO), due to its anti-inflammatory and antimicrobial properties, has been proposed for these treatments. The aim of our study was to demonstrate its short-term clinical efficacy in periodontal treatment.
Methods
This systematic review and meta-analysis was conducted in accordance with Cochrane guidelines, and searches were performed in PubMed, Embase, Cochrane Central, Scopus, and Web of Science (WOS) to identify eligible studies. Review Manager 5.4.1 and SPSS Statistics 30.0® were used to calculate standardized mean differences (SMD) and 95% confidence intervals (CI). The main outcomes assessed for periodontitis were probing depth (PPD), bleeding on probing (BoP), and clinical attachment level (CAL), and for gingivitis, plaque index (PI), gingival index (GI) and bleeding index (BI).
Results
Twelve randomized clinical trials (RCTs) involving 456 subjects were included. In periodontitis, compared with controls, OLO/OzOLO improved BoP reduction in the medium term (8-12 weeks) [-0.66; 95% CI (-1.07 to -0.26); p = 0.001], and no benefits were observed in terms of PPD reduction and CAL gain. In gingivitis, the effect of OLO/OzOLO, compared to controls, produced a significant reduction in all three indices (PI, GI, BI) after 2-8 weeks [-1.52, 95% CI (-2.60 to -0.44); p = 0.006].
Conclusions
Despite limitations, OLO/OzOLO treatments result in short-term CAL gain and improved gingival parameters.
Systematic review registration
doi: 10.37766/inplasy2025.10.0065, Identifier INPLASY 2025100065.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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