Omega-3 Fatty Acid Supplementation and Vascular Health Biomarkers - A Systematic Review and Meta-Analysis
Norouzzadeh M, Hasan Rashedi M, Hamidi N, Karimi-Javan N, Nourian S, Hasanpour M, Anoushirvani AA, Teymoori F
Journal of the American Nutrition Association · 1 cita
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-01-06 · J Am Nutr Assoc · vol. 45 · número 5 · págs. 428–440
- Editorial
- Taylor & Francis
- Citado
- 0 citas · más que el 1% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 85 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cancer, Lipids, and Metabolism · Liver Disease Diagnosis and Treatment
- Palabras clave
- Systematic review, Disease, Diabetes mellitus, MEDLINE, Fatty acid
- MeSH
- humans, cardiovascular diseases, fatty acids, omega-3, dietary supplements, randomized controlled trials as topic, pulse wave analysis, biomarkers, vascular health
8 autores
- Mostafa Norouzzadeh🇮🇷Iran University of Medical Sciences; Bushehr University of Medical Sciences
- Minoo Hasan Rashedi🇮🇷Iran University of Medical Sciences
- Niloofar Hamidi🇮🇷Iran University of Medical Sciences
- Negar Karimi-Javan🇮🇷Iran University of Medical Sciences
- Saeed Nourian🇮🇷Firoozgar General Hospital
- Mohammad Hasanpour🇮🇷Firoozgar General Hospital
- Ali Arash Anoushirvani🇮🇷Iran University of Medical Sciences
- Farshad Teymoori🇮🇷 · autor de correspondenciaIran University of Medical Sciences; Firoozgar General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cardiovascular diseases (CVDs) remain the leading global cause of death, partly due to vascular dysfunction. Dietary supplements, including omega-3 fatty acids, are suggested to support vascular health, but their therapeutic effectiveness and optimal dosing are still uncertain.
Objectives
This systematic review and meta-analysis study assessed the efficacy and dose-response effects of omega-3 fatty acids on vascular health biomarkers in individuals with CVDs.
Data sources
A comprehensive search of PubMed, Scopus, Web of Science, and the Cochrane Library was conducted through May 2025.
Study selection
Eligible randomized controlled trials (RCTs) with a minimum intervention duration of four weeks.
Data extraction and synthesis
Two reviewers independently extracted data and assessed study quality. Data were synthesized as weighted mean differences (WMDs) with 95% confidence intervals (CIs). Risk of bias was assessed using the Cochrane tool, and the certainty of the evidence (CoE) was appraised using the GRADE framework.
Main outcome(s) and measure(s)
The pulse wave velocity (PWV), augmentation index (AIx), and flow-mediated dilation (FMD).
Results
Twenty RCTs involving 1,208 participants were included, with 80% judged at low risk of bias. Omega-3 supplementation (0.3-4.7 g/day) showed no significant effect on PWV, including in subgroups with hypertension or established CVDs. In contrast, omega-3s improved AIx. FMD elevations were greater for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) than for alpha-linolenic acid. These findings were consistent across sensitivity analyses and supported by dose-response relationships, indicating that achieving approximately 1,650 mg EPA and 750 mg DHA may be important for optimizing vascular outcomes. The CoE ranged from moderate to low.
Conclusions
Omega-3 fatty acids may enhance endothelial function and reduce arterial wave reflection. Future trials with refined methods are needed to maximize clinical benefit.
Systematic review registration
Systematic review registered with PROSPERO, registration number CRD420251065121.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.