Omega-3 fatty acids and cardiovascular risk-related metabolic markers in diverse populations: a meta-analysis of randomized trials
Chen C, Li X, Yan H, Liu J, Cao Y, Zhao H, Liu S, Wang Y, Sun Y, Jia B, Yuan J
Nutrition, metabolism, and cardiovascular diseases : NMCD · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National College Students Innovation and Entrepreneurship Training Program
- Gobierno
- Shandong Provincial Postdoctoral Science Foundation
- Subvenciones
- Shandong Provincial Postdoctoral Science Foundation (SDCX-ZG-202400024); National Natural Science Foundation of China (82100854); National College Students Innovation and Entrepreneurship Training Program (202411065024)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2025-12-03 · Nutr Metab Cardiovasc Dis · vol. 36 · número 4 · pág. 104488
- Editorial
- Elsevier BV
- Citado
- 2 citas · más que el 59% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- Randomized controlled trial, Metabolic syndrome, Cardiovascular health, Polyunsaturated fatty acid, Triglycerides blood, Clinical trial
- MeSH
- humans, cardiovascular diseases, lipids, fatty acids, omega-3, treatment outcome, risk assessment, oxidative stress, dietary supplements, adult, aged, middle aged, female, male, dyslipidemias, adiponectin, randomized controlled trials as topic, young adult, biomarkers, heart disease risk factors, cardiometabolic risk factors
11 autores
- Chen Chen🇨🇳Qingdao University
- Xuan Li🇨🇳Qingdao University; Qingdao Municipal Hospital
- Hongli Yan🇨🇳Qingdao University
- Junyan Liu🇨🇳Qingdao University
- Yuhang Cao🇨🇳Qingdao University
- Hongjiao Zhao🇨🇳Qingdao University
- Shixin Liu🇨🇳Qingdao University
- Yilin Wang🇨🇳Qingdao University
- Yifei Sun🇨🇳Qingdao University
- Beili Jia🇨🇳 · autor de correspondenciaQingdao University; Qingdao Municipal Hospital
- Junhua Yuan🇨🇳 · autor de correspondenciaQingdao University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
Many studies reported the effects of n-3 polyunsaturated fatty acids (PUFA) towards cardiovascular risk, but results are inconclusive. This meta-analysis systemically explored PUFA-mediated effects on representative cardiovascular-related metabolic markers, including glycolipid profile, adiponectin, and oxidative stress indicators in different people.
Data synthesis
Literature search on PubMed, EMBASE, Web of Science, and the Cochrane Library were performed up to October 11, 2024. Randomized controlled trials focusing on the effects of n-3 PUFA supplementation on triacylglycerol (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), apolipoprotein, adipokine, hemoglobin A1c (HbA1c), c-reactive protein (CRP), and oxidative stress biomarkers were chosen as outcome variables. There were 24 studies with 2043 subjects showed significant effects: (1)TG decreased by 16.95 mg/dl (21 trials, n = 1491; 95 % CI: 23.25, -10.66), (2)HDL increased by 1.55 mg/dl (22 trials, n = 1914; 95 % CI: 0.69, 2.42), (3)adiponectin increased by 0.96 μg/ml (3 trials, n = 198; 95 % CI: 0.03, 1.8), (4)HbA1c decreased by 0.17 % (3 trials, n = 283; 95 % CI: 0.29, -0.04), (5)LDL decreased by 10.98 mg/dl in women (4 trials, n = 236; 95 % CI: 19.41, -2.5) and by 13.77 mg/dl in the polycystic ovary syndrome (PCOS) (3 trials, n = 180; 95 % CI: 22.83, -4.7), (6)TC decreased by 15.58 mg/dl in women (4 trials, n = 236; 95 % CI: 24.64, -6.53).
Conclusions
The meta-analysis indicates that n-3 PUFAs improve cardiovascular-related metabolic markers, potentially benefit cardiovascular health in patients with cardiovascular disease, PCOS, and kidney disease, especially in older women via reducing TG and HbA1c and increasing HDL and adiponectin.
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