The impact of intermittent fasting during weight reduction in people living with type 2 diabetes mellitus: a randomized clinical trial
M Abdel Fattah S, M Abbassi M, Abd Elshafy S, A Hegazy M, F Farid S
European journal of clinical nutrition · 1 cita
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-01-07 · Eur J Clin Nutr · vol. 80 · número 3 · págs. 299–306
- Editorial
- Springer Nature
- Citado
- 1 cita · más que el 88% de estudios similares · 4.0× el promedio de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diabetes Management and Research · Diet and metabolism studies
- Palabras clave
- intermittent fasting, type 2 diabetes, caloric restriction, weight loss, glycemic control, HbA1c, insulin resistance, HOMA-IR, medication reduction, body composition, waist circumference, physical activity, sedentary behavior, obesity treatment, fat mass, fasting insulin, fasting blood glucose
- MeSH
- humans, diabetes mellitus, type 2, weight loss, insulin, blood glucose, body mass index, caloric restriction, fasting, body composition, adult, middle aged, female, male, waist circumference, young adult, glycemic control, glycated hemoglobin, intermittent fasting
5 autores
- Salma M. Abdel Fattah🇪🇬 · autor de correspondenciaCairo University
- Maggie Abbassi🇪🇬Cairo University
- Samah Ahmed Abd elshafy🇪🇬Cairo University hospitals
- Mona Hegazy🇪🇬Cairo University
- Samar Farghali Farid🇪🇬Cairo University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Intermittent fasting (IF) has gained attention for weight management and metabolic health, but detailed trials comparing its efficacy to calorie restriction (CR) in type 2 diabetes mellitus (T2D) are limited. Our aim was to compare the impact of CR diet with or without 12-hour overnight IF regimen on weight loss, glycemic control, and reduction of medication use in T2D.
Methods
This was a 3-month, single-center randomized clinical trial. Participants (N = 99), 21-60 years with T2D, were randomly assigned to Group 1 (12-hour IF + CR, N = 48) or Group 2 (CR alone, N = 51). Anthropometric evaluations included weight, height, waist and hip circumference, and BMI. Body composition analysis was performed, and biochemical analysis included HbA1c, FBG, and fasting insulin levels to calculate the HOMA-IR. Physical activity was assessed using the Global Physical Activity Questionnaire.
Results
Both groups experienced significant weight loss after 12 weeks. The IF + CR group showed a more pronounced weight reduction (-6.51%) compared to the CR group (-4.41%) (P < 0.001) and significant improvements in HbA1c levels, with a reduction to 6.51% compared to 6.86% in the CR group (P = 0.035). The absolute reduction in HbA1c showed a significantly greater median decrease in the IF + CR group [-0.50 (IQR - 0.60 to -0.35)] compared with the CR group [-0.20 (IQR - 0.40 to -0.10)] (P = 0.002). IF + CR demonstrated significant reductions in waist circumference (-4.64%) and hip circumference (-3.12%) compared to the CR (-2.70% and -0.86%, respectively) (P < 0.05). Furthermore, IF + CR showed greater reductions in body fat mass (-9.39%) compared to the CR (-5.32%) (P < 0.001). Physical activity levels were comparable, with average MET of 100 and sedentary hours of 15.7 ( ± 3) for IF + CR and 16.2 ( ± 2.3) for CR, (P = 0.134).
Conclusions
A 12-hour intermittent fasting (IF) regimen combined with calorie restriction (CR) demonstrated superior efficacy in promoting weight loss and improving glycemic control in patients with type 2 diabetes (T2D) compared to CR alone. Integrating IF into clinical nutrition guidelines could offer a practical and effective approach to diabetes management.
Clinical trial registration
The study was registered at the Pan African Clinical Trial Registry (PACTR202411524439559).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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