Combined creatine and β-hydroxy-β-methylbutyrate supplementation with integral conditioning exercise enhances functional performance and metabolic health in physically active older adults: A randomized controlled crossover trial
Ramos-Hernández R, Busto N, Miguel-Ortega Á, Martínez-Ferrán M, Santamaría-Peláez M, Saiz-Rodríguez M, Mielgo-Ayuso J
Aging clinical and experimental research · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidad de Burgos
- Gobierno
- Junta de Castilla y León
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-09 · Aging Clin Exp Res · vol. 38 · número 1 · pág. 44
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 84% de estudios similares · 3.1× el promedio de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Cardiovascular and exercise physiology
- Palabras clave
- creatine monohydrate, beta-hydroxy-beta-methylbutyrate, dietary supplementation, older adults, multicomponent exercise training, functional performance, walking speed, sit-to-stand, Timed Up and Go test, basal metabolic rate, visceral fat, blood pressure, endothelial protein C receptor, inflammation, cardiopulmonary function, resistance training, endurance training, coordination training
- MeSH
- humans, creatine, valerates, exercise, cross-over studies, double-blind method, dietary supplements, aged, middle aged, female, male, physical functional performance
7 autores
- Rafael Ramos-Hernández🇪🇸Universidad de Burgos
- Natalia Barrallo Busto🇪🇸Universidad de Burgos
- Álvaro Miguel🇪🇸Universidad Alfonso X el Sabio
- María Martínez‐Ferrán🇪🇸Universidad de Burgos
- Mirian Santamaría-Peláez🇪🇸Universidad de Burgos
- Miriam Saiz‐Rodríguez🇪🇸Universidad de Burgos
- Juan Mielgo‐Ayuso🇪🇸 · autor de correspondenciaUniversidad de Burgos
Resumen
El texto original del estudio, en el idioma en que se publicó.
BACKGROUND: Combined creatine monohydrate (CRE) and β-hydroxy-β-methylbutyrate (HMB) supplementation may counteract age-related declines in functional capacity, yet evidence in physically active older adults is scarce. OBJECTIVE: To investigate the effects of six weeks of CRE + HMB supplementation integrated with a supervised multicomponent exercise program on functional performance, metabolic efficiency, and physiological health in older adults. METHODS: Thirty physically active adults aged ≥ 60 years (20 men, 10 women) completed a randomized, double-blind, placebo-controlled crossover trial involving two 6-week intervention phases (CRE + HMB or placebo), separated by a 3-week washout. The exercise program (4 sessions/week) combined strength, endurance, and coordination training. Functional tests (4-m gait speed, 5-repetition sit-to-stand, Timed Up and Go, 400-m walk), metabolic indices, and cardiopulmonary and inflammatory markers were assessed pre- and post-intervention. RESULTS: CRE + HMB significantly improved gait speed, sit-to-stand, TUG, and 400-m walk (p < 0.05), with large effect sizes (η²p = 0.15–0.29). Basal metabolic rate and metabolic rate index increased, while visceral adiposity showed favorable trends. Women exhibited reductions in diastolic blood pressure and higher expiratory strength; men showed a transient rise in endothelial protein C receptor (EPCR). No period, sequence, or carryover effects were detected. CONCLUSIONS: Six weeks of CRE + HMB supplementation integrated with supervised multicomponent training enhanced mobility, metabolic efficiency, and selected physiological outcomes in physically active older adults. This strategy represents a safe, feasible, and practical approach to sustain functional independence and metabolic health with aging.
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