The Role of Omega-3 Polyunsaturated Fatty Acid Supplementation in Postoperative Recovery of Colorectal Cancer: Systematic Review and Meta-Analysis
Li H, Xu Z, Chen Y, Guo J, Wang Q, Liang D, Qu P, Deng T, Yuan Y, Xu J, Fang H, Wang Z
Nutrients · 3 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- the National Key R&D Program of China
- Universidad u hospital
- National Center of Technology Innovation for Dairy
- Gobierno
- the National Key R&D Program of China
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-05 · Nutrients · vol. 18 · número 1 · pág. 173
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 6 citas · más que el 100% de estudios similares · 16.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Enhanced Recovery After Surgery · Nutrition and Health in Aging
- Palabras clave
- Polyunsaturated fatty acid, Colorectal cancer, Randomized controlled trial, Clinical trial, Albumin, Nutritional Supplementation, White blood cell, Pathological
- MeSH
- humans, colorectal neoplasms, postoperative complications, fatty acids, omega-3, postoperative period, dietary supplements, middle aged, female, male, randomized controlled trials as topic
12 autores
- Huzhong Li🇨🇳China National Center for Food Safety Risk Assessment
- Zhenze Xu🇨🇳Beijing Technology and Business University; China National Center for Food Safety Risk Assessment
- Yamin Chen🇨🇳China National Center for Food Safety Risk Assessment
- Jianming Guo
- Qihe Wang🇨🇳China National Center for Food Safety Risk Assessment
- Dong Liang🇨🇳China National Center for Food Safety Risk Assessment
- Pengfeng Qu🇨🇳China National Center for Food Safety Risk Assessment
- Taotao Deng🇨🇳China National Center for Food Safety Risk Assessment
- Yuan Yuan🇨🇳China National Center for Food Safety Risk Assessment
- Jiao Xu🇨🇳China National Center for Food Safety Risk Assessment
- Haiqin Fang🇨🇳 · autor de correspondenciaChina National Center for Food Safety Risk Assessment
- Ziyuan Wang🇨🇳 · autor de correspondenciaBeijing Technology and Business University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: China is currently developing standards for Food for Special Medical Purposes (FSMP) targeting for oncology patients. However, substantial challenges remain in defining optimal fortification levels of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). Accumulating evidence suggests that ω-3 PUFA intake improves postoperative prognosis by modulating oncological parameters in colorectal cancer (CRC) patients. This meta-analysis aimed to evaluate the therapeutic efficacy of ω-3 PUFA supplementation in enhancing postoperative safety and recovery stability following CRC surgery, to address critical gaps in nutritional interventions for optimizing clinical outcomes. These findings are expected to FSMP standard development, clinical nutrition protocols and product innovation. Methods: A systematic literature search was conducted, in accordance with PRISMA guidelines, across major databases until June 16, 2025. Data were analyzed using RevMan v5.4 (Cochrane Collaboration). Results: Thirty-four randomized controlled trials (RCTs) (n = 2889) were included. Compared to controls, the ω-3 PUFAs group showed significantly increased levels of nutritional markers: total protein (p p = 0.001); immunological parameters: CD3+/CD4+/CD8+ T-cells, CD4+/CD8+ ratio (all p p = 0.04); and serum ω-3 PUFA concentrations (p = 0.0004). Significant reductions were observed in inflammatory markers, such as procalcitonin, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) (p = 0.004 to p p p = 0.0005), surgical site infections (p = 0.03). No significant intergroup differences were detected for white blood cells, transcription factor activity, mortality, or crypt cell proliferation indices (p = 0.06-0.55). Conclusions: Overall, ω-3 PUFA supplementation significantly attenuates postoperative inflammation, enhances immune function, shortens hospitalization, and improves the quality of life in CRC patients, though without mortality benefit. Notably, post hoc dose-response analysis identified a supplementation range of 0.16-0.30 g/kg/day as a potentially optimal supplementation range for Chinese CRC populations, providing foundational evidence for clinical practice and FSMP standardization.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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