Association Between Dietary Magnesium Intake and Low Muscle Mass: The Mediating Role of Inflammatory Indicators
Zhu Z, Wang W, Ding F, Shen Y
Healthcare (Basel, Switzerland) · 0 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Science and Technology Commission of Shanghai Municipality
- Gobierno
- Shanghai Huangpu Industry Support Grant
- Subvenciones
- National Natural Science Foundation of China (81870462); National Natural Science Foundation of China (82100790); Science and Technology Commission of Shanghai Municipality (19441909300); National Natural Science Foundation of China (82070789)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-12-19 · Healthcare (Basel) · vol. 14 · número 1 · pág. 1
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 1 cita · más que el 69% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Nutrition and Health in Aging · Exercise and Physiological Responses
- Palabras clave
- National Health and Nutrition Examination Survey, Quartile, Mediation, Magnesium, Logistic regression, Inflammation, Dietary Reference Intake
4 autores
- Zhu Zhu🇨🇳Shanghai Ninth People's Hospital
- Wenji Wang🇨🇳Shanghai Ninth People's Hospital
- Feng Hua Ding🇨🇳 · autor de correspondenciaShanghai Ninth People's Hospital
- Yue Shen🇨🇳 · autor de correspondenciaShanghai Ninth People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Magnesium is essential for mitochondrial function and muscle regeneration, potentially protecting against low muscle mass (LMM). We examined the association of dietary magnesium intake with LMM risk and skeletal muscle index (SMI), and whether inflammatory indicators mediate this relationship. Methods: A total of 5793 participants aged 20-59 years were included in this study from the National Health and Nutrition Examination Survey (NHANES) conducted from 2011 to 2018. To investigate the association of dietary magnesium intake with LMM and SMI, we applied weighted logistic regression model, linear regression model, restricted cubic spline analysis, subgroup analysis and sensitivity analysis. Inflammatory indicators were assessed using mediation analysis, including the C-reactive protein-albumin-lymphocyte (CALLY) index, neutrophil-platelet score (NP), platelet-to-albumin ratio (PAR) and red blood cell distribution width-to-albumin ratio (RAR) mediation. Results: In the fully adjusted model, participants in the highest magnesium quartile had a reduced risk of LMM, with OR of 0.33 (95% CI: 0.18, 0.60), and increased levels of SMI, with β values of 0.05 (95% CI: 0.04, 0.07). Mediation analysis showed that NP, PAR, and RAR mediated 18%, 13%, and 21% of the association between magnesium and LMM, respectively, and also acted as mediators of the relationship between magnesium and SMI, with mediation ratios of 32%, 24%, and 25%, respectively. Conclusion: Higher dietary magnesium intake was associated with lower LMM risk and higher SMI, partly mediated through inflammatory indicators involving NP, PAR, and RAR. This finding may provide a new perspective on the prevention and management of LMM.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.