Cardiovascular effects of extra virgin olive oil in healthy reproductive-aged women: a randomized controlled trial
Morris EA, McBride CA, Roberts L, Psoinos R, Skelly J, Mandalà M, Bernstein IM
Pregnancy hypertension · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Larner College of Medicine, University of Vermont
- Universidad u hospital
- Cardiovascular Research Institute of Vermont, Larner College of Medicine, University of Vermont
- Universidad u hospital
- University of Vermont Larner College of Medicine
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-01-10 · Pregnancy Hypertens · vol. 43 · pág. 101411
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 76% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- extra virgin olive oil, cardiovascular function, insulin sensitivity, blood pressure, vascular distensibility, Mediterranean diet, inflammation, MCP-1, IL-10, LDL cholesterol, lipid profile, women of reproductive age, hypertension in pregnancy, sunflower oil, oleic acid, phenols
- MeSH
- humans, cardiovascular diseases, insulin resistance, insulin, cytokines, double-blind method, diet, mediterranean, pregnancy, blood pressure, dietary supplements, adult, female, biomarkers, olive oil
7 autores
- Erin A. Morris🇺🇸University of Vermont; University of Vermont Medical Center
- Carole A. McBride🇺🇸University of Vermont; University of Vermont Medical Center
- Lorinda M. Roberts🇺🇸University of Vermont; University of Vermont Medical Center
- Rachel B.C. Psoinos🇺🇸University of Vermont; University of Vermont Medical Center
- Joan M. Skelly🇺🇸University of Vermont
- Maurizio Mandalà🇺🇸🇮🇹 · autor de correspondenciaUniversity of Vermont; University of Calabria
- Ira M. Bernstein🇺🇸University of Vermont; University of Vermont Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Pregnant patients with cardiovascular and metabolic risk factors are at increased risk of hypertension in pregnancy. Adherence to Mediterranean-based diets high in extra virgin olive oil (EVOO) is associated with decreased risk. We performed a randomized, double-blind placebo-controlled trial of EVOO supplementation in reproductive-aged women to investigate its effects on cardiovascular function and markers of metabolic dysfunction and inflammation.
Study design
Healthy nulliparous women were randomized to 40 g/day of EVOO high in oleic acid and phenols or an identical dose of sunflower seed oil for 8 weeks. Cardiovascular assessment, lipid profiles, insulin sensitivity and serum cytokines were assessed at baseline and post intervention.
Main outcome measures
Blood pressure, vessel distensibility, metabolic assessment, serum cytokine levels.
Results
Twelve women in the EVOO group and 15 in the control group completed the trial. Compliance was >97 % in both groups. EVOO supplementation reduced fasting insulin (-0.31 ± 0.52 U/mL, p = 0.03), but increased LDL cholesterol (+5.1 ± 4.0 mg/dL, p = 0.047). No differences in blood pressure were observed, though EVOO was associated with a lower blood pressure response to volume challenge and a trend toward lower hemoglobin A1c (p = 0.06). IL-10 decreased in EVOO but increased in controls, -0.05 ± 0.03 vs +0.07 ± 0.03, p = 0.01). Unique to the EVOO group, a reduction in the chemokine MCP-1 positively correlated with a reduction in systolic blood pressure (r = 0.59, p = 0.042) and MAP (r = 0.59, p = 0.042).
Conclusions
EVOO supplementation in women of reproductive age may have beneficial metabolic and anti-inflammatory effects.
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