An exploratory, open-label, pilot randomized trial of omega-3 fatty acid supplementation on serum ferritin in university female students: The OMEGA-3 FA study
Fujibayashi M, Suganuma A, Domichi M, Hayashi I, Yamakata R, Fujikawa H, Kumano A, Kijima K, Tomokane S, Ogura Y, Sakane S, Sakane N
Clinical nutrition ESPEN · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Japan Society for the Promotion of Science
- Subvenciones
- Japan Society for the Promotion of Science (19K11512); Japan Society for the Promotion of Science (19K02369)
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-01-09 · Clin Nutr ESPEN · vol. 72 · pág. 102906
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 88% de estudios similares · 4.2× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Iron Metabolism and Disorders · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, serum ferritin, iron status, iron deficiency, female university students, omega-3 index, arachidonic acid, hepcidin, hemoglobin, lipidomics
- MeSH
- humans, anemia, iron-deficiency, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, hemoglobins, pilot projects, students, universities, dietary supplements, adolescent, adult, female, ferritins, young adult
12 autores
- Mami Fujibayashi🇯🇵Setsunan University
- Akiko Suganuma🇯🇵Kyoto Medical Center
- Masayuki Domichi🇯🇵Kyoto Medical Center
- Ikuyo Hayashi🇯🇵Kyoto Medical Center; Kyoto Kacho University
- Ryohei YAMAKATA🇯🇵Setsunan University
- Hiroyoshi Fujikawa🇯🇵Sonoda Women's University
- Aiko Kumano🇯🇵Kansai University of Social Welfare
- Kota Kijima🇯🇵Osaka University of Health and Sport Sciences
- Sayaka Tomokane🇯🇵Osaka University of Health and Sport Sciences
- Yukio Ogura🇯🇵Osaka International University
- Seiko Sakane🇯🇵Kyoto Medical Center
- Naoki Sakane🇯🇵 · autor de correspondenciaKyoto Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have unique properties that are advantageous for female. However, no study has explored the effects of omega-3 PUFA supplementation on serum ferritin levels. Thus, the objective of this study was to investigate the effects of omega-3 PUFA supplementation on serum ferritin levels in university female students.
Methods
Thirty-nine iron-deficient university female students aged 18-29 years randomly assigned in a 1:1 ratio to either the intervention group (receiving 525 mg eicosapentaenoic acid [EPA] and 175 mg docosahexaenoic acid [DHA] daily for 8 weeks) or the control group. Hemoglobin and serum ferritin levels, dietary intake, and lipidomics were assessed at baseline and after the 8-week intervention period. Analyses were performed by an independent, blinded statistician.
Results
The adherence rate in the study was 94.9 %. n-3 PUFA supplementation increased the omega-3 index (1.8 ± 1.7 vs. 0.4 ± 1.1; p = 0.007), while it decreased the omega-6/3 ratio (-2.6 ± 2.5 vs. -0.9 ± 1.5; p = 0.016) and arachidonic acid/EPA ratio (-9.1 ± 11.6 vs. 1.4 ± 8.5; p = 0.004) compared to those in the control group. These supplementation increased serum ferritin levels (7.8 ± 9.1 vs. 1.8 ± 8.0 ng/mL; p = 0.041); however, it did not change hemoglobin and hepcidin levels compared to those in the control group. No adverse events were observed.
Conclusion
In this pilot study, omega-3 PUFA supplementation was associated with modest changes in iron status markers in young healthy females. These findings are exploratory, and further placebo-controlled trials are needed to confirm the effects.
Name of trial registry
The effect of omega-3 fatty acids intake on hepcidin and anemia Identifying number: UMIN000050570.
Date of registration
2023/03/14.
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