Limited effects of dietary nitrate supplementation with resistance training on skeletal muscle and vascular outcomes in middle-aged and older adults
McIntosh MC, Mueller BJ, Tiede DR, Anglin DA, Kontos GJ, Plotkin DL, Mattingly ML, Kontos NJ, Michel JM, Agyin-Birikorang A, Harrison K, Peoples BM, Roper JA, Lewis DT, Chirico MK, Kannan H, Goodlett MD, Gladden LB, Frugé AD, Robinson AT, Kavazis AN, Beck DT, Roberts MD
American journal of physiology. Regulatory, integrative and comparative physiology · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Physiological Society
- Universidad u hospital
- Auburn University
- Universidad u hospital
- Edward Via College of Osteopathic Medicine
- Organización sin fines de lucro
- American Physiological Society (APS)
- Universidad u hospital
- Edward Via College of Osteopathic Medicine (VCOM)
- Universidad u hospital
- Auburn University (AU)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2026-01-12 · Am J Physiol Regul Integr Comp Physiol · vol. 330 · número 2 · págs. R136–R150
- Editorial
- American Physiological Society
- Citado
- 4 citas · más que el 98% de estudios similares · 12.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 83 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Exercise and Physiological Responses
- Palabras clave
- nitrate supplementation, resistance training, skeletal muscle hypertrophy, muscle strength, vascular function, middle-aged adults, older adults, untrained individuals, nitric oxide
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, age factors, neovascularization, physiologic, dietary supplements, aged, middle aged, female, male, muscle strength, resistance training, fruit and vegetable juices
23 autores
- Mason C. McIntosh🇺🇸Auburn University
- Breanna J. Mueller🇺🇸Auburn University
- Dakota Tiede🇺🇸Auburn University
- Derick A. Anglin🇺🇸Auburn University
- George J. Kontos🇺🇸Auburn University
- Daniel L. Plotkin🇺🇸Auburn University
- Madison L. Mattingly🇺🇸Auburn University
- Nicholas J. Kontos🇺🇸Auburn University
- John Max Michel🇺🇸Auburn University
- Anthony Agyin-Birikorang🇺🇸Auburn University
- Kenneth D. Harrison🇺🇸Auburn University
- Brandon M. Peoples🇺🇸Auburn University
- Jaimie A. Roper🇺🇸Auburn University
- Dustyn T. Lewis🇺🇸Auburn University
- M. Kase Chirico🇺🇸Auburn University
- Harshini Kannan🇺🇸Auburn University
- Michael D. Goodlett🇺🇸Auburn University
- L. Bruce Gladden🇺🇸Auburn University
- Andrew D. Frugé🇺🇸Auburn University
- Austin T. Robinson🇺🇸Indiana University
- Andreas N. Kavazis🇺🇸Auburn University
- Darren T. Beck🇺🇸 · autor de correspondenciaAuburn University; Edward Via College of Osteopathic Medicine
- Michael D. Roberts🇺🇸 · autor de correspondenciaAuburn University; Edward Via College of Osteopathic Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Increasing dietary nitrate (NO3-) through beetroot juice (BRJ) supplementation elicits acute ergogenic benefits. However, it is unknown whether chronic NO3- supplementation can enhance resistance training (RT) adaptations in middle-aged and older individuals. Therefore, we sought to determine whether 12 wk of combined RT and NO3- supplementation enhanced hypertrophic, vascular, strength, and skeletal muscle angiogenesis adaptations in this population. Twenty-eight apparently healthy, untrained men (M) and women (W) (56 ± 7 yr old and 29.1 ± 5.3 kg/m2 body mass index) completed 12 wk of supervised full-body RT (2×/wk) while ingesting either BRJ (140 mL daily, providing 800 mg NO3-; n = 14 with 7 M/7 W) or NO3--depleted BRJ placebo (PLA; n = 14 with 7 M/7 W). Participants underwent a whole body dual-energy X-ray absorptiometry scan, right mid-thigh ultrasonography for muscle imaging, right leg popliteal artery flow-mediated dilation (FMD) assessments, a biopsy of the right mid-thigh vastus lateralis, and strength testing before and following the 12-wk intervention. Biopsy analyses included a NO3-/nitrite (NOx) fluorometric assay, immunoblotting for proteins involved in angiogenesis, and immunohistochemistry to quantify fiber type-specific capillaries and cross-sectional areas. Muscle NOx values did not significantly change: +15.4% in BRJ (P = 0.073) and +7.8% (P = 0.514) in PLA. Both groups significantly improved measures related to muscle hypertrophy, strength, and FMD. However, no significant group × time interactions were observed for whole body lean mass, mid-thigh muscle cross-sectional area, popliteal artery FMD outcomes, or histological or molecular markers. In conclusion, these preliminary data on a limited number of participants indicate that BRJ supplementation does not enhance RT adaptations in middle-aged and older adults.NEW & NOTEWORTHY Results from this study suggest that 12 wk of dietary nitrate supplementation does not significantly alter skeletal muscle hypertrophic, strength, or vascular outcomes in previously untrained middle-aged and older adults who performed resistance training.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.