Effects of low-level LED red-light therapy on axial elongation in hyperopic children: A bidirectional cohort study
Li Y, Zhou C, Ji Q, Ding G, Qi X, Li X, Li J, Qian X
Photodiagnosis and photodynamic therapy · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-01-10 · Photodiagnosis Photodyn Ther · vol. 57 · pág. 105341
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 89% de estudios similares · 5.2× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Ophthalmology and Visual Impairment Studies · Intraocular Surgery and Lenses
- Palabras clave
- Elongation, Refractive error, Cohort study, Prospective cohort study, Eye disease
- MeSH
- humans, hyperopia, cohort studies, adolescent, child, child, preschool, female, male, axial length, eye, low-level light therapy, red light
8 autores
- Ya Li🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Chuyu Zhou🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Qingyun Ji🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Gang Ding🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Xiaoli Qi🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Xue Li🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Jing Li🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Xuehan Qian🇨🇳 · autor de correspondenciaTianjin Medical University Eye Hospital; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To investigate whether low-level LED red-light therapy promotes axial elongation in hyperopic children.
Methods
This bidirectional cohort study included 201 hyperopic children aged 4 -13 years. Participants were divided into two groups: the LED group (n = 51), who received low-level LED red-light therapy, and the spectacle-only comparison group (n = 150). Axial length (AL) was measured at baseline and each follow-up. Longitudinal changes in AL were analyzed using a linear mixed-effects model (LMM). Inverse probability of treatment weighting (IPTW) was performed as a sensitivity analysis to minimize potential confounding. In a subgroup of 40 anisometropic children who received unilateral LED treatment, interocular comparisons between treated and fellow eyes were conducted using paired t-tests, and within-subject LMM analyses to assess eye-specific treatment effects.
Results
The LED group showed a significantly faster rate of axial elongation than the comparison group (interaction β=+0.082 mm/year, 95% CI: 0.042 to 0.122; p < 0.001). In the anisometropic subgroup, treated eyes elongated significantly faster than fellow eyes (mean difference = +0.167 mm/year, 95% CI: 0.109-0.226; p < 0.001), leading to a reduction in interocular axial length disparity. LMM confirmed a greater time-dependent increase in treated eyes (β = +0.151 mm/year, 95% CI: 0.102-0.199; p < 0.001).
Conclusions
Low-level LED red-light therapy significantly accelerates axial elongation in hyperopic children and reduces interocular differences in anisometropic cases, suggesting that it may promote more balanced binocular refractive development.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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