Comparison of oral ketorolac and oral magnesium for postoperative pain management in anorectal surgery: A randomized double-blind clinical trial
Eshagh Hoseini SJ, Ghazi FS, Eshraghi M, Vahedian M, Pashaei MR, Bahadorzadeh M, Ahmadpour S
The Journal of international medical research · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-01 · J Int Med Res · vol. 54 · número 1 · pág. 3000605251409937
- Editorial
- SAGE Publishing
- Citado
- 0 citas · más que el 4% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Inflammatory mediators and NSAID effects · Anesthesia and Pain Management · Anorectal Disease Treatments and Outcomes
- Palabras clave
- Ketorolac, Analgesic, Randomized controlled trial, Adverse effect, Clinical trial, Narcotic, Postoperative pain
- MeSH
- rectum, humans, magnesium, ketorolac, anti-inflammatory agents, non-steroidal, pain measurement, administration, oral, double-blind method, adult, aged, middle aged, anal canal, female, male, pain management, postoperative pain
7 autores
- Seyed Jalal Eshagh Hoseini🇮🇷Shahid Beheshti University of Medical Sciences
- Farzaneh Sadat Ghazi🇮🇷Qom University of Medical Science and Health Services
- Mohsen Eshraghi🇮🇷Shahid Beheshti University of Medical Sciences
- Mostafa Vahedian🇮🇷Qom University of Medical Science and Health Services
- Mohammad Reza Pashaei🇮🇷Urmia University; Urmia University of Medical Sciences
- Mojdeh Bahadorzadeh🇮🇷 · autor de correspondenciaShahid Beheshti University of Medical Sciences
- Sajjad Ahmadpour🇮🇷 · autor de correspondenciaUrmia University; Urmia University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
ObjectivePostoperative pain is one of the most common complications after anorectal surgery and can delay recovery, lengthen hospital stay, and reduce patient comfort. Non-steroidal anti-inflammatory drugs are widely used due to their strong analgesic and opioid-sparing effects but are associated with gastrointestinal, renal, and bleeding risks. Magnesium may provide analgesic benefits with fewer adverse effects. However, evidence regarding its efficacy in the oral form and direct comparison with non-steroidal anti-inflammatory drugs remains limited. In this study, we aimed to compare the analgesic effectiveness of oral magnesium with that of oral ketorolac to identify the more suitable analgesic drug in these patients.MethodsIn this double-blind, randomized controlled trial, 104 patients undergoing anorectal surgery were randomly divided into 2 groups. Group 1 received oral magnesium (250 mg daily), and Group 2 received oral ketorolac (10 mg daily). The medicine was given to the patients 2 h after the operation and then every 12 h for 10 days. Pain levels were measured at 24-hour intervals after the surgery using the visual analog scale.ResultsBoth treatments significantly reduced postoperative pain over time (p p p = 0.089 and 0.092, respectively). Narcotic consumption was higher in the magnesium group than in the ketorolac group (p < 0.001).ConclusionsOral magnesium demonstrated a clinically meaningful analgesic effect comparable to that of oral ketorolac from postoperative day 5 onward, suggesting that it is a safe non-opioid alternative for postoperative pain management in anorectal surgery. Further multicenter trials with larger samples are warranted to confirm these findings.
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