Walnut peptide and theanine combination ameliorates sleep disorders: a multi-species study including a human trial
Gong J, Jia X, Wang L, Lu Y, Guo R, Gong R, Hao J, Zhao Z, Duan S, Liu X, He J, Li H, Liu Z
Food & function · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-01-01 · Food Funct · vol. 17 · número 3 · págs. 1199–1213
- Editorial
- Royal Society of Chemistry
- Citado
- 1 cita · más que el 93% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 73 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and related disorders · Sleep and Wakefulness Research · Circadian rhythm and melatonin
- Palabras clave
- walnut peptides, theanine, sleep disorders, chronic stress, slow-wave sleep, hypothalamic-pituitary-adrenal axis, corticosterone, GABA, tryptophan, sleep quality, dietary intervention, zebrafish, pentylenetetrazole
- MeSH
- pituitary-adrenal system, hypothalamo-hypophyseal system, animals, mice, inbred c57bl, zebrafish, humans, mice, juglans, disease models, animal, corticosterone, glutamates, peptides, sleep, adult, female, male, young adult, sleep wake disorders, sleep duration, bioactive peptides, dietary
13 autores
- Jun Gong🇨🇳Northwest A&F University
- Xiuzhen Jia
- Lei Wang🇨🇳Northwest A&F University
- Lu Yiwu🇨🇳Northwest A&F University
- Rui Guo🇨🇳Northwest A&F University
- Gong Ruihan🇨🇳Northwest A&F University
- Hao Jingyu
- Zhao Zifu
- Sufang Duan
- Xuebo Liu🇨🇳Northwest A&F University
- jian He
- Hongwei Li🇨🇳Xiamen University
- Zhigang Liu🇨🇳Northwest A&F University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Chronic stress-induced sleep disorders are characterized by disrupted sleep architecture and a significant reduction in slow-wave sleep (SWS). These disorders represent a major public health challenge and are mechanistically linked to the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. This study employed a translational research paradigm-including zebrafish screening, a chronic unpredictable mild stress (CUMS) mouse model, and an eight-week randomized, placebo-controlled human trial-to evaluate the efficacy of a combination of walnut peptide and theanine (WPT). Treatment with WPT reduced waking activity and duration in pentylenetetrazole (PTZ)-induced zebrafish. In CUMS mice, the combination significantly improved sleep architecture by restoring the duration of SWS and enhanced sleep quality by increasing delta wave power density. Mechanistically, the intervention corrected hypothalamic-pituitary-adrenal (HPA) axis hyperactivity by lowering elevated serum corticosterone (CORT) levels. Furthermore, it modulated central neurotransmitters, notably reversing stress-induced deficits by increasing the levels of the inhibitory neurotransmitter GABA and tryptophan, a key precursor for serotonin and melatonin. In the human trial, the WPT restored sleep duration and improved subjective sleep quality scores (assessed by the Pittsburgh Sleep Quality Index, PSQI). In conclusion, this translational study provides robust evidence that the WPT effectively improves chronic stress-induced sleep disorders in zebrafish and mice, and improves sleep disturbances in adults (PSQI ≥ 7) by regulating HPA axis function and restoring the duration and quality of SWS. This makes it a highly promising nutritional intervention strategy.
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