Time-Restricted Eating to Improve Metabolic Abnormalities in Polycystic Ovarian Syndrome (TimeMAP)
Floyd R, Dyer A, Gibney J, Alawami F, Owens L, Phelan N, Rakovac A, Swan P, LeRoux CW, Behan LA, Duggan SN
Clinical endocrinology · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Queen's University Belfast
- Universidad u hospital
- Queen's University
- Organización sin fines de lucro
- Meath Foundation
- Organización sin fines de lucro
- The Meath Foundation
Según 4 financiadores declarados.
Publicación
- Publicado
- 2026-01-14 · Clin Endocrinol (Oxf) · vol. 104 · número 4 · págs. 327–342
- Editorial
- Wiley
- Citado
- 2 citas · más que el 96% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Ovarian function and disorders · Enhanced Recovery After Surgery
- Palabras clave
- time-restricted eating, polycystic ovary syndrome, hyperinsulinemia, insulin resistance, HbA1c, weight loss, anthropometric indices, dietary intervention, intervention feasibility, crossover design
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, insulin, blood glucose, cross-over studies, patient compliance, adult, female, young adult, intermittent fasting
11 autores
- Ruairí Floyd🇮🇪 · autor de correspondenciaTrinity College Dublin; Tallaght University Hospital
- Adam Dyer🇮🇪Trinity College Dublin
- James Gibney🇮🇪Trinity College Dublin; Tallaght University Hospital
- Fatimah Alawami🇮🇪Tallaght University Hospital
- Lisa Ann Owens🇮🇪Trinity College Dublin; St. James's Hospital
- Niamh Phelan🇮🇪Trinity College Dublin; St. James's Hospital
- Ana Rakovac🇮🇪Tallaght University Hospital
- Patrick Swan🇮🇪University College Dublin
- Carel Wynand le Roux🇮🇪University College Dublin
- Lucy‐Ann Behan🇮🇪Trinity College Dublin; Tallaght University Hospital
- Sinead Noelle Duggan🇬🇧Queen's University Belfast
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Time-restricted eating (TRE) represents a novel intervention that may improve hyperinsulinaemia and reduce weight, but has not been studied in polycystic ovarian syndrome (PCOS). In a randomised interventional study (NCT05126199 [1]), we investigated the feasibility of TRE in PCOS including recruitment, compliance, safety, drop-out rate, and effect on insulin-related parameters, anthropometrics, nutritional intake and metabolic indices.
Methods
Participants were randomised to a 12-week TRE regimen (18 h fast/6 h eating window) or 'ad libitum' regimen (no time-restriction), and then crossed over to the alternative regimen for a further 12 weeks.
Results
TRE was a feasible intervention with near-total compliance in those completing the intervention; however, there were considerable difficulties with recruitment. A total of 70 were eligible to participate, of which ultimately 15 were recruited, and 11 completed the study (4 [27%] drop-outs due to commitment/study duration). There were no serious adverse events in the TRE group. Compliance [%(SD)] with TRE was 94.7(4.5)%, and 10 participants were keen to continue the intervention post-study. Whilst the study was not powered to detect changes in metabolic or anthropometric indices, exploratory analysis showed a decrease in HbA1c (p = 0.04), weight (p = 0.001), BMI (p = 0.001), hip circumference (p = 0.05) and waist circumference (p = 0.001) in the TRE group compared to the ad libitum eating group.
Conclusion
In a 12-week cross-over feasibility study, TRE was a safe and feasible intervention. Recruitment was challenging and with limited numbers, the TRE group showed a decrease in HbA1c and anthropometric indices compared to the 'ad libitum' group.
Trial registration
NCT05126199.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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