Quantitative sensory testing of pain in osteoporosis: a pilot randomized clinical trial with magnesium supplementation
Pickering ME, Morel V, Nicolas M, Dualé C, Sortais E, Graven-Nielsen T, Pereira B, Pickering G
Aging clinical and experimental research · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Universidad u hospital
- University Hospital Clermont-Fd
- Empresa
- APICIL Foundation
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-21 · Aging Clin Exp Res · vol. 38 · número 1 · pág. 67
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 3% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Bone health and osteoporosis research · Pain Mechanisms and Treatments · Musculoskeletal pain and rehabilitation
- Palabras clave
- magnesium supplementation, zoledronic acid, bisphosphonates, pain sensitivity, conditioned pain modulation, thermal pain threshold, analgesic effect, pain modulation, anxiety, depression, sleep quality, fracture risk
- MeSH
- humans, osteoporosis, postmenopausal, pain, magnesium, diphosphonates, pain measurement, pilot projects, pain threshold, dietary supplements, aged, middle aged, female, bone density conservation agents, zoledronic acid
8 autores
- Marie‐Eva Pickering🇫🇷 · autor de correspondenciaUniversité Clermont Auvergne; Unité de Nutrition Humaine; Centre Hospitalier Universitaire de Clermont-Ferrand
- Véronique Morel🇫🇷Inserm; Centre Hospitalier Universitaire de Clermont-Ferrand
- Nicolas Macian🇫🇷Inserm; Centre Hospitalier Universitaire de Clermont-Ferrand
- Christian Dualé🇫🇷Inserm; Centre Hospitalier Universitaire de Clermont-Ferrand
- Elise Sortais🇫🇷Inserm; Centre Hospitalier Universitaire de Clermont-Ferrand
- Thomas Graven‐Nielsen🇩🇰Aalborg University
- Bruno Pereira🇫🇷Centre Hospitalier Universitaire de Clermont-Ferrand
- G T Pickering🇫🇷Inserm; Université Clermont Auvergne; Centre Hospitalier Universitaire de Clermont-Ferrand
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Bisphosphonates (BP) are a recommended treatment for osteoporosis and an analgesic effect has been suggested. Magnesium is involved in pain mechanisms, mood disorders and also in bone homeostasis. Association of BPs and magnesium has however not been studied to explore pain processes in post-menopausal osteoporosis.
Methods
In this pilot ancillary study of a randomized clinical trial in post-menopausal osteoporosis, women were randomized to standard care with intravenous Zoledronate (BP group, n = 22) or BP with oral magnesium (BPMg group, n = 22), 200 mg/day for 3 months. Endpoints were quantified before and 1 year after treatment as spontaneous pain, anxiety, depression and sleep quality, as well as quantitative sensory testing of pain sensitivity by thermal thresholds and conditioned pain modulation (CPM), a psychophysical marker of the functionality of pain modulation at spinal level.
Results
Thirty-five women (68.2 ± 7.3 years old) with post-menopausal osteoporosis completed the analysis. Compared with baseline, magnesium supplementation did not change significantly any of the endpoints. CPM at baseline was low (-0.92 ± 1.14) and not reversed by treatment.
Conclusions
This study in post-menopausal osteoporosis underlines for the first time that zoledronate or zoledronate with magnesium have no effect on pain characteristics and thresholds. It shows a dysfunction of pain inhibitory pain pathways and its non-reversibility with treatments. It points towards the lack of any analgesic effect of zoledronate, and above all to a latent vulnerability of osteoporotic women who are at a potential risk of fracture with a poor pain modulation that needs to be researched further to limit future chronification.
Trial registration number
(NCT05328154), 15/03/2022.
Trial
Protocol, statistical analysis plan, participant data and other materials (including data dictionary) can be accessed on request to the corresponding author.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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