Influence of omega-3 fatty acids on post-traumatic stress disorder: prospective cohort study and Mendelian randomisation findings
Chen M, Huang H, Liu Y, Hou C, Chen S
European journal of psychotraumatology · 0 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Guangdong Medical Science and Technology Research Fund
- Gobierno
- Guangdong Provincial Foundation for Basic and Applied Basic Research Natural Science Foundation
- Gobierno
- Guangzhou Science and Technology Projects
- Subvenciones
- National Natural Science Foundation of China (82470531)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-26 · Eur J Psychotraumatol · vol. 17 · número 1 · pág. 2605801
- Editorial
- Taylor & Francis
- Citado
- 1 cita · más que el 89% de estudios similares · 4.2× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Fatty Acid Research and Health · Posttraumatic Stress Disorder Research · Migration, Health and Trauma
- Palabras clave
- omega-3 fatty acids, post-traumatic stress disorder, plasma fatty acids, trauma exposure, causal relationship, sex differences, omega-3 supplementation, mental health
- MeSH
- humans, fatty acids, omega-3, prospective studies, stress disorders, post-traumatic, adult, middle aged, female, male, mendelian randomization analysis, united kingdom
5 autores
- Miaona Chen🇨🇳Southern Medical University
- HaoZhang Huang🇨🇳 · autor de correspondenciaGuangdong Academy of Medical Sciences; Southern Medical University
- Yong Liu🇨🇳Guangdong Academy of Medical Sciences; Southern Medical University
- Cailan Hou🇨🇳 · autor de correspondenciaSouthern Medical University
- Shiqun Chen🇨🇳 · autor de correspondenciaGuangdong Academy of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and Objectives: Omega-3 fatty acids have positive effects on mental health. This study aimed to explore the association between plasma omega-3 fatty acid levels and the risk of post-traumatic stress disorder (PTSD).Methods: This study explored the association between plasma omega-3 fatty acid levels and risk of developing PTSD. In total, 82,391 adults from the UK Biobank were included in this study. PTSD screening was performed using a PCL-6 score greater than 13, based on responses to the online mental health questionnaire. Multivariate logistic regression analyses were performed to evaluate the association between omega-3 fatty acid levels and the risk of PTSD. Additionally, a two-sample bidirectional Mendelian randomisation (MR) analysis was used to investigate potential causal relationships.Results: A significant association was found between high omega-3 fatty acid levels and a lower risk of PTSD. For each 1 unit increase in omega-3 fatty acids, the adjusted odds ratio (OR) was 0.75 (p = 9.05E-05); for each 1% increase in total fatty acids, the adjusted OR was 0.95 (p = 4.30E-07). Among the population that has experienced catastrophic traumatic exposure, the results remained consistent. MR analysis indicated that high omega-3 levels and omega-3/total fatty acid ratios were causally linked to a reduced risk of PTSD (per 1 unit increase, OR = 0.99; p = .029; per 1% increase, OR = 0.98; p = .037). Conversely, PTSD was causally associated with lower omega-3 levels (beta = -0.203, p = 2.12E-05) and a lower omega-3/total fatty acids ratio (beta = -0.266, p = 1.52E-07). Subgroup analyses revealed that females might benefit more significantly (OR = 0.64, p = 3.59E-07; p-interaction = .010).Conclusions: This study suggests a negative association between PTSD and omega-3 fatty acids, indicating that omega-3 supplementation may be an effective preventive and therapeutic strategy for PTSD.
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