Predawn Versus Preiftar Timing of Levothyroxine Administration During Ramadan Intermittent Fasting: A Multicenter Randomized Controlled Trial
Alamoudi RM, Nawar S, Al Mulla A, Alharbi H, Alqarni A, Alzahrani AM, Busaad W, Alahmari N, Alshamrani N, Alkhalifa L, Saleh Y, Ramadan M, Borai A
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of National Guard Health Affairs
- Universidad u hospital
- King Abdullah International Medical Research Center
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-01-01 · Endocr Pract · vol. 32 · número 5 · págs. 745–751
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 5% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 11 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Thyroid Disorders and Treatments · Dietary Effects on Health · Thyroid and Parathyroid Surgery
- Palabras clave
- levothyroxine, Ramadan fasting, intermittent fasting, primary hypothyroidism, thyroid-stimulating hormone, free thyroxine, timing of drug administration, patient satisfaction, medication adherence
- MeSH
- humans, hypothyroidism, thyrotropin, thyroxine, fasting, drug administration schedule, islam, adult, middle aged, patient satisfaction, saudi arabia, female, male, intermittent fasting
13 autores
- Reem Mohammad Alamoudi🇸🇦 · autor de correspondenciaKing Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Samah M. Nawar🇸🇦National Guard Health Affairs
- Abdulrhman Khaled Almulla🇸🇦King Abdulaziz Medical City; National Guard Health Affairs
- Hibah Saleh Alharbi🇸🇦National Guard Health Affairs
- Ali Alqarni🇸🇦King Abdullah International Medical Research Center; National Guard Health Affairs
- Abdulla Alzahrani🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
- Walaa Tawfeeq Busaad🇸🇦King Abdulaziz Hospital; National Guard Health Affairs
- Nasser Faris Ali Alahmari🇸🇦King Abdulaziz Medical City; National Guard Health Affairs
- Nouf Daghash Alshamrani🇸🇦King Abdulaziz Medical City; National Guard Health Affairs
- Lujain Alkhalifa🇸🇦King Abdulaziz Medical City; National Guard Health Affairs
- Yousef Mohd Saleh🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; National Guard Health Affairs
- Majed M. Ramadan🇸🇦King Abdullah International Medical Research Center
- Anwar Borai🇸🇦King Saud bin Abdulaziz University for Health Sciences; King Abdulaziz Medical City; King Abdullah International Medical Research Center; National Guard Health Affairs
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To compare 2 levothyroxine (LT4) dosing regimens during Ramadan: preiftar and predawn, with respect to thyroid biochemical control and patient satisfaction.
Methods
This multicenter, open-label randomized controlled trial recruited adults with primary hypothyroidism from 3 Saudi cities (Jeddah, Riyadh, and Al-Ahsa). Patients with thyroid cancer were excluded. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels were measured 2 weeks before and 4 to 6 weeks after Ramadan. Participants were randomized to take LT4 either before breaking the fast (preiftar) or just before fasting began (predawn).
Results
A total of 303 (156 preiftar and 147 predawn) participants completed the study. Groups were comparable in demographic characteristics and comorbidities. Mean age was 49 ± 12 years; 87% were female; mean disease duration was 9.7 ± 8.3 years. Weekly LT4 dose was 753 ± 349 μg (preiftar) versus 733 ± 266 μg (predawn; P = .001). Pre-Ramadan TSH level was 2.56 ± 2.16 mIU/L versus 2.46 ± 1.72 mIU/L (P = .3), and FT4 level was 13.45 ± 2.1 versus 13.08 ± 2.4 pmol/L (P = .16). Post-Ramadan TSH level was 3.64 ± 4.1 versus 4.07 ± 4.2 mIU/L (P = .78), and FT4 level was 12.96 ± 0.1 versus 12.64 ± 0.2 pmol/L (P = .003). Within-group post-Ramadan changes were nonsignificant. Repeated measures analysis of variance showed no significant differences in TSH or FT4 levels over time or between groups (P = .47 and P = .81). Compliance and satisfaction were comparable.
Conclusion
Both preiftar and predawn LT4 regimens maintained thyroid stability during Ramadan. Either can be safely adopted according to patient preference.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.