Dietary magnesium intake and dementia risk in community-dwelling people aged 40-74 years: an 8-year cohort study
Bulycheva I, Watanabe Y, Kitamura K, Kabasawa K, Saito T, Takahashi A, Kobayashi R, Oshiki R, Takachi R, Tsugane S, Yamazaki O, Watanabe K, Nakamura K
Journal of nutritional science · 1 cita
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-01 · J Nutr Sci · vol. 15 · pág. e12
- Editorial
- Cambridge University Press
- Citado
- 1 cita · más que el 89% de estudios similares · 4.3× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Heavy Metal Exposure and Toxicity
- Palabras clave
- Dementia, Quartile, Hazard ratio, Cohort study, Proportional hazards model, Disease, Cohort
- MeSH
- humans, dementia, magnesium, diet, proportional hazards models, risk factors, cohort studies, adult, aged, middle aged, japan, female, male, independent living, aging in place
13 autores
- Irina A. Bulycheva🇯🇵Niigata University
- Yumi Watanabe🇯🇵Niigata University
- Kaori Kitamura🇯🇵Niigata University
- Keiko Kabasawa🇯🇵Niigata University
- TOSHIKO SAITO🇯🇵Niigata University
- Akemi Takahashi🇯🇵Niigata University of Rehabilitation
- Ryosaku Kobayashi🇯🇵Niigata University of Rehabilitation
- Rieko Oshiki🇯🇵Niigata University of Rehabilitation
- Ribeka Takachi🇯🇵Nara Women's University
- Shoichiro Tsugane🇯🇵International University of Health and Welfare
- Osamu Yamazaki🇯🇵Chiba Prefectural Government; Niigata Prefectural Government
- Kei Watanabe🇯🇵Niigata University
- Kazutoshi Nakamura🇯🇵 · autor de correspondenciaNiigata University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary magnesium (Mg) is a potentially modifiable factor in preventing dementia, but current evidence supporting this remains insufficient and inconclusive. This study aimed to determine whether dietary Mg is associated with the risk of dementia among middle-aged and older people. Participants of this 8-year cohort study were 13,032 community-dwelling individuals aged 40-74 years. Dietary data were collected using a validated food frequency questionnaire in 2011-2013. Mg intake was adjusted for energy intake using the residual method. The outcome was newly diagnosed dementia determined using Japan's long-term care insurance database. Covariates included demographic characteristics, body size, lifestyles, and disease histories. Cox proportional hazard models were used to determine adjusted hazard ratios (HRs). The mean age of participants was 59.0 years. Dementia occurred in 148 males and 138 females. Lower quartiles of energy-adjusted Mg intake were associated with a higher risk of dementia (P for trend = 0.0410) in males, with the lowest quartile (Q1) having an elevated risk of dementia (HR = 1.73, 95% CI:1.07-2.83) compared to the highest quartile (Q4, reference); however, this association was not found in females. In a subgroup analysis by disease history in males, the HR of Q1 was attenuated in both subgroups; HR was 1.52 (95% CI:0.74-3.11) in those with a disease history and 1.40 (95% CI:0.73-2.69) in those without. In conclusion, low dietary Mg intake is associated with increased dementia risk in middle-aged and older Japanese males. However, this association may be partly attributable to underlying disease history.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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