Efficacy and safety of Ashwagandha (<i>Withania somnifera</i>) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study
Pakhale K, Pakhale R, Srivathsan M, Langade J, Langade D
Journal of medicine and life · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-12-01 · J Med Life · vol. 18 · número 12 · págs. 1140–1154
- Editorial
- Carol Davila University of Medicine and Pharmacy Publishing House
- Citado
- 3 citas · más que el 92% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Pharmacological Effects of Medicinal Plants · Biofield Effects and Biophysics
- Palabras clave
- Withania somnifera, root extract, stress reduction, weight management, body weight, body mass index, perceived stress, quality of life, food cravings, adverse events, herbal supplement safety
- MeSH
- humans, withania, plant roots, body weight, plant extracts, body mass index, prospective studies, double-blind method, stress, psychological, quality of life, adult, aged, middle aged, female, male, young adult
5 autores
- Ketan Pakhale
- Rajshree K. Pakhale
- Mayakalyani Srivathsan🇮🇳D.Y. Patil University
- Jayshree Langade
- Deepak Langade🇮🇳D.Y. Patil University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The relationship between excess body weight and stress significantly impacts overall health. The current study evaluated the efficacy and safety of Ashwagandha (Withania somnifera) root extract (ARE) in altering stress biomarkers and its role in weight management. In this prospective, randomized, double-blind, placebo-controlled study, 100 participants (age: 19-65 years) were randomized to receive either ARE 300 mg twice daily (n = 50) or an identical placebo (PL, n = 50) for 24 weeks. The primary efficacy endpoints were changes in body weight and body mass index (BMI). Secondary endpoints included evaluation of stress (Perceived Stress Scale, PSS), quality of life (Short Form-12 Quality of Life Scale), subjective satisfaction (Subjective Satisfaction Scale, SSS), and food cravings (Food Cravings Questionnaire-Trait, FCQ-T). Clinical safety was assessed based on treatment-emergent adverse events (TEAEs) and laboratory parameters, including complete blood count, renal function tests, liver function tests, lipid profile, thyroid function tests, and glycemic parameters (plasma glucose and glycated hemoglobin). Efficacy was analyzed in 91 patients. ARE administration resulted in a significant reduction in body weight (-8.46 ± 3.86 kg; P 2; P 2 for body weight and BMI, respectively). Compared with PL, ARE showed significant improvements (P < 0.05) in PSS, SF-12, SSS, and FCQ-T scores. A total of seven participants with ARE and six with PL reported mild adverse events (nausea, abdominal pain, and drowsiness), which were resolved without any intervention. Ashwagandha root extract may offer a safe and beneficial approach for stress reduction and weight management.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.