Omega-3 fatty acids and oral and systemic inflammation: A secondary analysis of a randomized trial in patients with coronary artery disease
Ahmad B, Daher R, Malik A, Jeong YN, Welty FK
Journal of the American Dental Association (1939) · 1 cita
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Dental and Craniofacial Research
- Gobierno
- Center for Scientific Review
- Gobierno
- National Institutes of Health Center for Scientific Review
- Gobierno
- NIDCR NIH HHS
- Subvenciones
- National Institute of Dental and Craniofacial Research (RO1 DE18814); Center for Scientific Review (P50 HL083813); National Institutes of Health (UL1 TR001102)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2026-02-05 · J Am Dent Assoc · vol. 157 · número 8 · págs. 819–827
- Editorial
- Elsevier BV
- Citado
- 3 citas · más que el 98% de estudios similares · 12.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Oral microbiology and periodontitis research · Antioxidant Activity and Oxidative Stress
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, gingival crevicular fluid, oral inflammation, systemic inflammation, macrophage inflammatory protein-1β, neutrophil-to-lymphocyte ratio, periodontal disease, coronary artery disease, statin therapy, handedness, toothbrushing behavior, powered toothbrushes, cardiovascular risk
- MeSH
- neutrophils, gingival crevicular fluid, humans, inflammation, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, hydroxymethylglutaryl-coa reductase inhibitors, dietary supplements, aged, middle aged, female, male, coronary artery disease, chemokine ccl4
5 autores
- Bushra Ahmad🇺🇸Tufts University
- Ralph Daher🇺🇸Cooper University Health Care
- Abdulaziz Malik🇺🇸Tufts Medical Center
- Y. Natalie Jeong🇺🇸Tufts University
- Francine K. Welty🇺🇸 · autor de correspondenciaBeth Israel Deaconess Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Given the recognized link between periodontal disease and cardiovascular conditions, the authors tested whether omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), could reduce key inflammatory markers.
Methods
In this secondary analysis, 240 patients with stable coronary artery disease undergoing statin therapy were randomized to receive 3.36 g/d of EPA and DHA (test group) or no supplementation (control group) for 30 months. Of these, 199 patients had gingival crevicular fluid collected in the maxillary left and right quadrants. Oral and systemic inflammatory markers were compared.
Results
The EPA and DHA group had significantly lower gingival crevicular fluid levels of macrophage inflammatory protein-1β in the left quadrant (P = .038) and a lower systemic neutrophil to lymphocyte ratio (P = .021) than the control group. The authors hypothesized that handedness may account for the localized anti-inflammatory effect in the left quadrant because right-handed people have better plaque removal on the left side.
Conclusions
EPA and DHA supplementation lowered oral and systemic inflammation, potentially contributing to improved periodontal health and reducing cardiovascular risk. The site-specific difference may be influenced by means of handedness or toothbrushing behavior and warrants further investigation.
Practical implications
Supplementation with EPA and DHA can complement mechanical oral hygiene. Recommending powered toothbrushes may eliminate handedness-related differences, providing a more uniform anti-inflammatory effect alongside EPA and DHA supplementation. This clinical trial was registered at ClinicalTrials.gov. The registration number is NCT01624727.
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