Secondary prevention of leg cramps using compression stockings or magnesium supplements: a three-arm randomized clinical trial
Kuusipalo A, Laitila J, Lehtonen E, Joensuu J, Mustajoki P, Mustonen P, Huhtala H, Kaila M, Koskela TH
Trials · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Tays
- Organización sin fines de lucro
- Lydia and Karl G. Lindberg’s Duodecim foundation
- Universidad u hospital
- Tampere University
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-02-13 · Trials · vol. 27 · número 1
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 93% de estudios similares · 7.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Diagnosis and Treatment of Venous Diseases · Body Contouring and Surgery · Magnesium in Health and Disease
- Palabras clave
- Randomized controlled trial, Secondary prevention, Compression stockings, Magnesium, Clinical trial, Compression (physics)
- MeSH
- humans, muscle cramp, sleep-wake transition disorders, magnesium, pain measurement, treatment outcome, time factors, aged, aged, 80 and over, middle aged, finland, female, male, stockings, compression
9 autores
- Arno Kuusipalo🇫🇮 · autor de correspondenciaTampere University of Applied Sciences; Tampere University
- Juhani Laitila🇫🇮Tampere University
- Eemil Lehtonen🇫🇮Tampere University
- Jenni Joensuu🇫🇮Pirkanmaa Hospital District
- Pertti Mustajoki🇫🇮University of Helsinki
- Pekka Mustonen🇫🇮Finnish Medical Society Duodecim
- Heini Huhtala🇫🇮Tampere University
- Minna Kaila🇫🇮Finnish Medical Society Duodecim
- Tuomas Koskela🇫🇮Tampere University; Tampere University Hospital; Tampere University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Leg cramps are common among older adults and often lead to sleep disturbances and reduced quality of life. However, there is no consensus on how to treat this condition. This study aimed to evaluate the effectiveness of compression stockings in preventing leg cramps in individuals aged 50 to 85.
Methods
This study was a three-arm, parallel-group, partially blinded, randomized placebo-controlled trial conducted in Finland. Participants were recruited nationwide through online advertisements and primary care centers. Eligible individuals had experienced at least two leg cramps per week during the previous 4 weeks. Participants were randomized to receive either knee-high medical compression stockings, magnesium hydrochloride, or placebo pills, to be used daily for 4 weeks. The primary outcome was the change in leg cramp frequency at week 8. Secondary outcomes included the number of leg cramp-related nocturnal awakenings and the perceived pain intensity on an ordinal scale.
Results
A total of 121 participants were randomized, and 109 (90.1%) completed the trial. The primary outcome analysis included 114 participants. The mean age was 65.8 years (SD 7.8), and 87 (71.9%) were women. At baseline, the median number of weekly leg cramps was 4 (IQR 3-7). At week 8, the median weekly leg cramp frequency was 2 (IQR 1-2.5) in the compression stockings group, 3 (IQR 2-6) in the magnesium group, and 3 (IQR 2-5) in the placebo group. The baseline-adjusted mean difference in leg cramp frequency between the compression stockings and placebo group was -1.43 (95% CI -2.36 to -0.50; P = .001). No significant difference was observed between the magnesium and placebo groups, with an adjusted mean difference of -0.20 (95% CI -1.49 to 1.09; P = 0.929). Four participants discontinued compression stockings due to adverse reactions. No serious adverse events were reported.
Conclusions
Among older adults, daily use of compression stockings was effective in reducing the frequency and pain intensity of leg cramps, as well as the number of nocturnal awakenings caused by them.
Trial registration
ClinicalTrials.gov NCT04694417. Registered on 4 January 2021.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.