Financiado en parte por Sunao Pharma Inc. (Japan).
Hyperoside-Rich Blueberry Leaf Tea Improves Sleep Continuity in Adults with Poor Sleep: A Two-Week Randomized Double-Blind Controlled Trial
Shoji K, Yuasa T, Kitajima Y, Hirakawa Y
Nutrients · 1 cita
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Sunao Pharma Inc. (Japan).
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-30 · Nutrients · vol. 18 · número 3 · pág. 453
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 1 cita · más que el 94% de estudios similares · 8.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Sleep and related disorders · Medicinal Plant Extracts Effects · Circadian rhythm and melatonin
- Palabras clave
- hyperoside, fermented tea, sleep quality, sleep continuity, sleep efficiency, wake after sleep onset, sleep fragmentation, functional foods, serotonergic pathways, actigraphy
- MeSH
- humans, plant leaves, quercetin, double-blind method, sleep, tea, adult, aged, middle aged, female, male, young adult, sleep wake disorders, blueberry plants, sleep quality, sleep duration
4 autores
- Kentaro Shoji🇯🇵 · autor de correspondenciaOtsuma Women's University
- Tomonori Yuasa🇯🇵Miyazaki Prefecture Foods Development Center
- Yui Kitajima🇯🇵Otsuma Women's University
- Yoshiko Hirakawa🇯🇵Miyazaki Prefecture Foods Development Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Sleep is fundamental to physical and mental health, yet many individuals experience impaired sleep quality. Although pharmacological interventions are available, they are associated with risks of dependency and adverse effects, underscoring the urgent need for safer, food-based alternatives. Blueberry leaves, rich in hyperoside, are suggested to influence sleep through serotonergic and melatonergic pathways; however, while their potential to help maintain sleep quality has been noted, the sleep-enhancing effects of fermented blueberry leaf tea have not yet been demonstrated. This present randomized, double-blind, placebo-controlled trial evaluated the sleep-enhancing effects of fermented blueberry leaf tea on sleep quality.
Methods
Fifty adults (aged 20-69 years) reporting poor sleep were randomly assigned to consume either fermented blueberry leaf tea (n = 25) or placebo tea (n = 25) three times daily for two weeks. Objective sleep parameters-sleep efficiency, wake after sleep onset (WASO), sleep latency, and total sleep time-were assessed using actigraphy, while subjective sleep quality was evaluated using the Oguri-Shirakawa-Azumi Sleep Inventory MA (OSA-MA) version questionnaire.
Results
In the per-protocol analysis (active: n = 22; placebo: n = 20), the active group exhibited significant improvements in sleep efficiency and WASO compared with the placebo (p < 0.05). No significant differences were observed for sleep latency, total sleep time, or subjective assessments. Importantly, baseline sleep efficiency and WASO were negatively correlated with their respective improvements, suggesting that individuals with poorer initial sleep benefited most.
Conclusions
These findings demonstrate that fermented blueberry leaf tea may enhance sleep continuity within two weeks, particularly among individuals with fragmented sleep, and support the potential role of functional foods in sleep health strategies.
Trial registration
University Hospital Medical Information Network (UMIN), UMIN000055879; registered on 21 October 2024.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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