Process Evaluation of a Time-Restricted Eating Intervention for Weight Management in South African Women Living with Overweight/Obesity and HIV on Dolutegravir-Based Antiretroviral Therapy: A Qualitative, RE-AIM-Informed Analysis
Hoosen F, Goedecke JH, Dave JA, Quist JS, Færch K, Grunnet LG, Mendham AE
Nutrients · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Carnegie Corporation of New York
- Organización sin fines de lucro
- European Foundation for the Study of Diabetes
- Gobierno
- Fonds National de la Recherche Luxembourg
- Gobierno
- National Research Fund, South Africa
- Subvenciones
- Carnegie Corporation of New York (G-21-58838); Fonds National de la Recherche Luxembourg (141970)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-02-01 · Nutrients · vol. 18 · número 3 · pág. 474
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 6% de estudios similares · 0.0× el promedio de su campo
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- 0 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Health Policy Implementation Science · HIV/AIDS Research and Interventions
- Palabras clave
- time-restricted eating, weight management, HIV, overweight and obesity, dolutegravir, antiretroviral therapy, type 2 diabetes, food insecurity, implementation barriers and facilitators, treatment acceptability, participant retention, Khayelitsha
- MeSH
- humans, hiv infections, obesity, oxazines, piperazines, pyridones, heterocyclic compounds, 3-ring, anti-retroviral agents, qualitative research, adult, middle aged, south africa, female, overweight, intermittent fasting, southern african people, dolutegravir
7 autores
- Fatima Hoosen🇿🇦 · autor de correspondenciaUniversity of Cape Town
- Julia H. Goedecke🇿🇦South African Medical Research Council; University of Cape Town
- Joel Alex Dave🇿🇦University of Cape Town
- Jonas Salling Quist🇩🇰🇬🇧University of Copenhagen; University of Leeds; Copenhagen University Hospital; Steno Diabetes Center Copenhagen
- Kristine Færch🇩🇰Copenhagen University Hospital; Steno Diabetes Center Copenhagen; Aalborg University
- Louise Groth Grunnet🇩🇰Copenhagen University Hospital; Steno Diabetes Center Copenhagen
- Amy E. Mendham🇿🇦🇦🇺University of Cape Town; Riverland Mallee Coorong Local Health Network
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: South Africa faces the world's highest HIV burden, disproportionately affecting women, alongside rising Type 2 Diabetes (T2D). Weight gain associated with preferred dolutegravir (DTG)-based antiretroviral therapy may worsen obesity and T2D risk. This process evaluation explored the implementation of a 12-month time-restricted eating (TRE) intervention for weight management in women with HIV and overweight/obesity in Khayelitsha, Cape Town. Methods: Using the RE-AIM framework, the study investigated the implementation journey. Data were collected from three groups: RCT participants, healthcare workers (n = 21), and fieldworkers (n = 3). Methods included structured informal interviews with TRE participants throughout the intervention and semi-structured in-depth interviews (IDIs) with a subset (n = 19) at 12 months. IDIs and focus group discussions were conducted with healthcare staff. Results: Implementation faced significant contextual challenges, including high food insecurity, economic constraints, and high crime levels. Cultural norms around food hospitality also posed barriers. Despite this, TRE was highly feasible and acceptable. Participants reported positive behavioural changes, establishing eating routines and consuming healthier foods. Perceived health benefits included improved appetite control, wellbeing, sleep, and weight management. Key facilitators were the intervention's flexibility and, importantly, the non-judgmental, empathetic support from fieldworkers, which drove engagement and retention. Healthcare workers expressed willingness to integrate TRE into existing HIV counsellor-led services, and nearly all participants desired to continue TRE post-intervention. Conclusions: This process evaluation demonstrates that TRE is a contextually suitable and acceptable intervention from an implementation perspective. Its success in practice, however, depends on mitigating complex multi-level barriers through a flexible program design and high-quality, relationship-focused support integrated into existing healthcare infrastructure. Trial registration: PACTR202302484999720, 8 February 2023.
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