Caffeine intake and late dry age-related macular degeneration: tea's protective role-insights from NHANES and Mendelian randomization
Yang H, Liu B, Zhang Y, Zhang Z, Tan H, Li X
International journal of retina and vitreous · 0 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Gobierno
- Tianjin Key Medical Discipline (Specialty) Construction Project
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-02-16 · Int J Retina Vitreous · vol. 12 · número 1
- Editorial
- BioMed Central
- Citado
- 0 citas · más que el 7% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Retinal Diseases and Treatments · Coffee research and impacts · Retinal Development and Disorders
- Palabras clave
- caffeine consumption, dry age-related macular degeneration, geographic atrophy, tea consumption, coffee consumption, dose-response relationship, regulatory T cells, CD4+ T cells, NHANES, Mendelian randomization
6 autores
- Hongli Yang🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Boshi Liu🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Yunxi Zhang🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Zhanhe Zhang🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Huang Tan🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Xiaorong Li🇨🇳 · autor de correspondenciaTianjin Medical University Eye Hospital; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although caffeine is widely consumed and has demonstrated neuroprotective effects, its role in age-related macular degeneration (AMD) remains unclear, particularly across disease subtypes and dietary sources such as tea and coffee.
Methods
We analyzed 2005-2008 NHANES data using weighted logistic regression and restricted cubic splines to assess the dose-response relationship between caffeine intake and the prevalence of early and late AMD. Two-sample Mendelian randomization (MR) using GWAS summary statistics was employed to evaluate causal effects of tea and coffee consumption on AMD subtypes. Furthermore, a two-step MR approach was utilized to identify potential immune-mediated pathways.
Results
NHANES data showed that caffeine intake was inversely associated with late AMD (fully adjusted OR = 0.65, 95% CI: 0.44-0.96). Dose-response modeling revealed an L-shaped nonlinear relationship (P for nonlinear = 0.046), indicating that the protective effect of caffeine plateaued once daily intake exceeded approximately 110-150 mg. MR analysis further supported a causal protective association between tea consumption and dry AMD, including geographic atrophy (OR = 0.44, 95% CI: 0.20-0.97), which may be partially attributable to immunological mechanisms, specifically the downregulation of secretory regulatory T cells (% of CD4 + Tregs) and CD45RA- CD4 + T cell (% of CD4 + T cell). In contrast, coffee consumption showed no significant effect.
Conclusions
Tea, a specific source of caffeine typically corresponding to moderate intake levels, may confer protection against dry AMD, including geographic atrophy, potentially through modulation of immune cell profiles. These findings suggest a potential preventive strategy and warrant further clinical investigation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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