Financiado en parte por Ixoreal BioMed Inc.
Ashwagandha ( Withania somnifera ) Root Extract Improves General Health in Elderly Men and Women: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study
Honnutagi R, Ingale A, Naikawdi A
Phytotherapy research : PTR · 2 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Ixoreal BioMed Inc.
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-02-22 · Phytother Res · vol. 40 · número 8 · págs. 4932–4945
- Editorial
- Wiley
- Citado
- 2 citas · más que el 98% de estudios similares · 19.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Biofield Effects and Biophysics · Pharmacological Effects of Medicinal Plants
- Palabras clave
- Withania somnifera, root extract, adaptogens, herbal medicine, older adults, quality of life, sleepiness, physical fitness, tolerability, functional limitations
- MeSH
- humans, withania, plant roots, plant extracts, phytotherapy, prospective studies, double-blind method, quality of life, aged, aged, 80 and over, middle aged, female, male
3 autores
- R. Honnutagi🇮🇳Shri BM Patil Medical College
- Anand Ingale🇮🇳S Nijalingappa Medical College and HSK Hospital & Research Centre
- Akram Naikawdi🇮🇳 · autor de correspondenciaShri BM Patil Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Ashwagandha (Withania somnifera), an adaptogen, is widely used in traditional Indian medicine for its health benefits in elderly people with functional limitations and physical disabilities. This double-blind, randomized, placebo-controlled clinical trial study assessed the efficacy and safety of a standardized Ashwagandha Root Extract (ARE) on general health improvement in elderly. Fifty (32 male, 18 female) healthy people aged between 60 and 85 years who consented to participate were randomly assigned to receive either capsule ARE 300 mg twice daily orally (n = 25) or an identical placebo (n = 21) for 8 weeks. The primary efficacy outcome was change in scores for Older People's Quality of Life (OPQOL) questionnaire, whereas secondary outcomes were change in scores for the Epworth Sleepiness Scale (ESS), and Senior Fitness Test (SFT). Clinical safety was evaluated using adverse events and global assessment of tolerability to therapy (GATT) by the physician. Greater improvement in OPQOL scores was observed with ARE, compared to placebo at both week 4 (p = 0.023) and week 8 (p < 0.0001), and these differences were observed in all sub-scales of OPQOL. Patients receiving ARE showed higher improvements after week 8 for total scores for ESS (p < 0.001), and SFT sub-scales (p < 0.01). The majority of participants on ARE reported excellent to good tolerability (96.0%). No adverse events were reported in the ARE group, while one patient reported nausea and headache in the placebo group. Ashwagandha root extract can be a useful herbal intervention for the improvement of general health and quality of life in elderly men and women.
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