Effects of time-restricted eating on blood pressure in children: A cluster randomized controlled trial
Wu X, Miao J, Peng Z, An X, Liu Q, Chen L, Liang X
Clinical and experimental hypertension (New York, N.Y. : 1993) · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-02-24 · Clin Exp Hypertens · vol. 48 · número 1 · pág. 2635384
- Editorial
- Informa
- Citado
- 0 citas · más que el 12% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC
- Áreas de investigación
- Dietary Effects on Health · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Palabras clave
- time-restricted eating, blood pressure, children, adolescents, hypertension prevention, eating window, systolic blood pressure, diastolic blood pressure, school-based intervention, attrition, cluster randomization, multiple imputation, missing data, intention-to-treat analysis, mixed models, sleep timing, circadian rhythm
- MeSH
- humans, hypertension, cluster analysis, blood pressure, time factors, adolescent, child, female, male, intermittent fasting
7 autores
- Xiaofei Wu🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Jingkun Miao🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Zhilian Peng
- Xizhou An🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Qin Liu🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Lanling Chen🇨🇳Children's Hospital of Chongqing Medical University; Chongqing Medical University
- Xiaohua Liang🇨🇳 · autor de correspondenciaChildren's Hospital of Chongqing Medical University; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
This study aimed to evaluate the safety and efficacy of a time-restricted eating (TRE) intervention to reduce blood pressure (BP) in children and adolescents.
Methods
We conducted a 12-month, three-arm cluster-randomized controlled trial in two schools, with classes as the unit of randomization (91 classes). Children and adolescents with elevated BP were allocated to TREa (12-hour eating window with the last meal before 8:00 PM), TREb (12-hour eating window without a fixed last mealtime), or control (no time restriction). A total of 192 participants were enrolled and analyzed under an intention-to-treat framework (64 per group). Follow-up completion (retention) rates were 65.1% (125/192) at 6 months and 59.4% (114/192) at 12 months, corresponding to loss-to-follow-up rates of 34.9% (67/192) and 40.6% (78/192), respectively. Analyses used mixed-effects models accounting for clustering, with multiple imputations as a sensitivity analysis for missing data.
Results
After 12 months of intervention, both the TREa and TREb groups showed significant reductions in BP, with TREa demonstrating the most significant changes. Systolic blood pressure (SBP) decreased significantly in the TREa (-7.03 mmHg, 95%CI, -10.77 to -3.29 mmHg; P P = 0.013). Diastolic blood pressure (DBP) changes in the TREa group were -4.09 mmHg (-6.80 to -1.38 mmHg; P P = 0.006).
Conclusions
A 12-hour eating window, particularly with the last meal completed before 8 PM, may be associated with lower BP over 12 months in children and adolescents with elevated BP; interpretation should consider the cluster design and attrition.
Trial registration
ChiCTR2400090073 (retrospectively registered on 23 September 2024).
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