Vitamin D and Bisphosphonate Therapy for Optimizing Outcomes in Spinal Fusion: A Systematic Review and Meta-Analysis
Sadh P, Kim J, Furlong C, Perez-Albela A, Suleman Y, Basques BA
Spine · 0 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-02-23 · Spine (Phila Pa 1976) · vol. 51 · número 14 · págs. 1041–1048
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 0 citas · más que el 11% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 20 trabajos
- Acceso
- De pago
- Áreas de investigación
- Spine and Intervertebral Disc Pathology · Vitamin D Research Studies · Spinal Fractures and Fixation Techniques
- Palabras clave
- vitamin D supplementation, bisphosphonates, spinal fusion, fusion rate, vertebral compression fractures, postural stability, patient-reported disability, pain, bone turnover markers, bone mineral density, osteoporosis
- MeSH
- humans, spinal fractures, diphosphonates, vitamin d, treatment outcome, spinal fusion, bone density conservation agents
6 autores
- Puru Sadh🇺🇸Brown University
- Jinseong Kim🇺🇸Brown University
- Charles Furlong🇺🇸Georgetown University
- Alejandro Perez‐Albela🇺🇸Brown University
- Yousuf Suleman🇺🇸Brown University
- Bryce A. Basques🇺🇸 · autor de correspondenciaBrown University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Study design
Systematic review and meta-analysis.
Objective
To systematically evaluate the impact of perioperative vitamin D supplementation and bisphosphonate therapy on spinal fusion outcomes, patient-reported disability and pain, postural stability, and vertebral fracture risk.
Background
Bone health optimization is critical for successful spinal fusion. While vitamin D and bisphosphonate supplementation have been studied individually, their comparative and combined effects remain unclear.
Methods
A PRISMA-compliant systematic review and meta-analysis were performed (PubMed, Embase, and Google Scholar; through January 2025). Eligible randomized controlled and prospective comparative trials evaluated: (1) vitamin D versus placebo/no supplement and (2) bisphosphonates versus vitamin D. Primary outcomes were fusion rates and vertebral compression fractures (VCFs). Secondary outcomes included functional scores (ODI), VAS, postural stability, bone turnover markers (P1NP), and BMD. Risk ratios (RR) and mean differences (MD/SMD) with 95% CI were pooled.
Results
For the vitamin D versus placebo analysis, increased fusion at one year (RR: ∼1.25), improved ODI at six months and one year (MD: ∼6.90, 8.56), and provided a small early VAS benefit (MD: 1.14). OSI improved significantly (SMD: 0.93). For Bisphosphonates versus vitamin D analysis, bisphosphonate therapy accelerated early fusion, but by one year, outcomes were similar. ODI favored vitamin D at one year, while VAS showed no difference. Bisphosphonates suppressed P1NP and reduced fracture risk (RR: 0.10).
Conclusions
Vitamin D accelerates early fusion and modestly improves long-term function and bisphosphonates provide fracture protection and turnover suppression. These findings support a tailored, multimodal approach to perioperative bone health optimization in spinal fusion.
Level of evidence
Level II.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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