Financiado en parte por This research was funded by WATER LAB s.r.o., Olšanská 2989/4h, 130 00 Praha-Žižkov, Czech Republic (IČ 04091299, DIČ CZ04091299). The Article Processing Charge (APC) was funded by WATER LAB s.r.o.
Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial
Stolecka-Warzecha A, Zając T, Gandyk M, Kostrzewa M, Sadowska-Krępa E
Nutrients · 0 citas
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- This research was funded by WATER LAB s.r.o., Olšanská 2989/4h, 130 00 Praha-Žižkov, Czech Republic (IČ 04091299, DIČ CZ04091299). The Article Processing Charge (APC) was funded by WATER LAB s.r.o.
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-02-21 · Nutrients · vol. 18 · número 4 · pág. 694
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 9% de estudios similares · 0.0× el promedio de su campo
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- 0 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Hydrogen's biological and therapeutic effects · Antioxidant Activity and Oxidative Stress
- Palabras clave
- exercise-induced inflammation, oxidative stress, interleukin-6, malondialdehyde, lipid peroxidation, hydration, physically active adults, plasma biomarkers
- MeSH
- humans, inflammation, water, malondialdehyde, interleukin-6, exercise, oxidation-reduction, lipid peroxidation, oxidative stress, drinking, adult, female, male, young adult, biomarkers
5 autores
- Anna Stolecka‐Warzecha🇵🇱 · autor de correspondenciaMedical University of Silesia
- Tomasz Zając🇵🇱Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach
- Marcin Gandyk🇵🇱Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach
- Maciej Kostrzewa🇵🇱Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach
- Ewa Sadowska‐Krępa🇵🇱Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Acute high-intensity exercise induces transient inflammatory and oxidative stress responses, mediated by redox-sensitive signaling pathways and reflected by elevations in interleukin-6 (IL-6) and lipid peroxidation products. Modulation of these responses through hydration-based redox interventions remains insufficiently characterized at the biochemical level.
Objective
This randomized controlled trial investigated whether regular consumption of redox (alkaline) water influences exercise-induced inflammatory and oxidative stress markers in physically active adults.
Methods
Forty physically active adults were randomized into an experimental group (EG; n = 20) and consumed redox water subjected to molecular-level modification, yielding alkaline hydrogen-enriched water (pH 9.2-9.4), or a control group (CG; n = 20) that consumed standard water. After eight weeks of intervention, participants performed a standardized maximal aerobic exercise test. Plasma IL-6 and malondialdehyde (MDA) concentrations were measured at baseline and immediately post-exercise. Statistical analyses included two-way repeated measures ANOVA and ANCOVA.
Results
A pronounced group × time interaction was observed for IL-6 (F(1,38) = 36.89, p p = 0.029), reflecting stable lipid peroxidation levels in the EG and increased levels in the CG; however, baseline-adjusted analyses indicated that post-exercise MDA differences were largely attributable to initial variability. Hematological and coagulation parameters remained within physiological ranges in both groups.
Conclusions
Redox water intake was associated with lower immediate post-exercise IL-6 compared with controls after baseline adjustment; however, pronounced baseline imbalance limits causal interpretation and warrants confirmation in larger trials with balanced inflammatory profiles. These findings highlight a potential biochemical mechanism linking hydration redox properties with inflammatory regulation during physical stress.
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