Acute kidney injury biomarker responses in young and older female adults following mild hypohydration
Domeier C, Robinson AT, Babcock MC, Vondrasek JD, Bissen TG, Muñoz CX, Smith KA, Watso JC
American journal of physiology. Renal physiology · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Universidad u hospital
- Florida State University
- Gobierno
- National Institutes of Health
- Organización sin fines de lucro
- American Heart Association (AHA)
- Organización sin fines de lucro
- Institute for Successful Longevity
- Gobierno
- NHLBI NIH HHS
- Gobierno
- HHS | National Institutes of Health
- Gobierno
- HHS | National Institutes of Health (NIH)
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- American Heart Association (25PRE1354834); American Heart Association (23CDA1037938); National Institutes of Health (K01 HL147998); National Institutes of Health (K01HL164978); National Institutes of Health (K01 HL160772)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2026-02-27 · Am J Physiol Renal Physiol · vol. 330 · número 4 · págs. F456–F466
- Editorial
- American Physical Society
- Citado
- 2 citas · más que el 97% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Thermoregulation and physiological responses · Acute Kidney Injury Research · Electrolyte and hormonal disorders
- Palabras clave
- Renal function, Biomarker, Cystatin C, Urine, Urinary system, Acute kidney injury, Urine osmolality, Excretion
- MeSH
- kidney, humans, dehydration, insulin-like growth factor binding proteins, tissue inhibitor of metalloproteinase-2, cross-over studies, water deprivation, age factors, renin-angiotensin system, aging, osmolar concentration, adult, aged, middle aged, female, cystatin c, young adult, acute kidney injury, biomarkers, lipocalin-2
8 autores
- Christin Domeier🇺🇸Florida State University
- Austin T. Robinson🇺🇸Indiana University
- Matthew C. Babcock🇺🇸University of Colorado Anschutz
- Joseph D. Vondrasek🇺🇸Florida State University
- Thomas G. Bissen🇺🇸Florida State University
- Colleen X. Muñoz🇺🇸University of Hartford
- Kyle A. Smith🇺🇸Florida State University
- Joseph C. Watso🇺🇸 · autor de correspondenciaFlorida State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Hypohydration reduces kidney function and increases acute kidney injury (AKI) risk. Aging increases hypohydration-induced kidney dysfunction in males, but female aging studies are lacking. Therefore, we compared the effects of mild hypohydration on kidney function and AKI biomarkers in young (YF) and older female adults (OF). In a random crossover design, 17 YF (20-35 yr old) and 9 OF (55-75 yr old), who were apparently healthy, completed two hydration protocols with ≥1 wk washout: 1) baseline hydration, and 2) stepwise water restriction over 3 days, concluding with 16 h water deprivation. We assessed hydration, AKI biomarkers, and the renin-angiotensin-aldosterone system (RAAS) from blood and 24-h urine samples. The effects of age group and condition were assessed using two-way mixed-effects analysis and reported as means ± SD. Hypohydration increased urine specific gravity and osmolality (condition effect: P P = 0.04), independent of age (P = 0.62). Urine cystatin C excretion increased in YF (P P = 0.69), with a significant interaction effect (P = 0.017). Nephrin excretion and product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2 (IGFBP7 × TIMP-2) increased after hypohydration (both P P ≥ 0.35). OF exhibited lower plasma renin activity than YF (P = 0.046), with no other main or interaction effects for other RAAS markers. OF did not exhibit greater AKI biomarker responses to mild hypohydration, contrasting with male studies showing age-related kidney function decline. These results highlight the need for research to clarify potential sex-based differences in age-related decline in kidney function.NEW & NOTEWORTHY This is the first study to assess the effects of mild hypohydration on acute kidney injury biomarkers in young and older female adults. Mild hypohydration altered acute kidney injury biomarker concentrations in both age groups, with no observed age-related differences, contrasting with male studies that show an age-related decline. These findings highlight the need for targeted research on potential sex-related differences in kidney function decline with aging.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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