Caloric restriction and time-restricted eating in older adults with overweight or obesity: The Health, Aging, and Later-Life Outcomes Pilot Study
Houston DK, Fanning J, Nicklas BJ, Delany JP, Hsu FC, Chen SH, Walkup M, Neiberg RH, Stowe CL, Kennedy K, Espeland MA, Ard JD, Miller ME, Rejeski WJ, Kritchevsky SB
The journals of gerontology. Series A, Biological sciences and medical sciences · 1 cita
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Cómo se estudió
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Quién lo pagó
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- Financiación independiente
- Universidad u hospital
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- University of Pennsylvania
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- Wake Forest University
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- School of Medicine, Boston University
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- Perelman School of Medicine, University of Pennsylvania
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- Medical School, University of Michigan
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- National Institute on Aging
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- NIA NIH HHS
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- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute on Aging (P30 AG021332); National Institute on Aging (U01AG073240); Wake Forest University (P30 AG021332); Wake Forest University (UL1 TR001420); National Center for Advancing Translational Sciences (TR001420); National Center for Advancing Translational Sciences (P30AG021332); National Center for Advancing Translational Sciences (UL1TR001420)
Según 13 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-02-27 · J Gerontol A Biol Sci Med Sci · vol. 81 · número 4
- Editorial
- Oxford University Press
- Citado
- 1 cita · más que el 90% de estudios similares · 4.0× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Nutrition and Health in Aging
- Palabras clave
- caloric restriction, time-restricted eating, older adults, obesity, overweight, body composition, physical performance, cardiometabolic risk factors, glucose, cholesterol, intervention feasibility, participant retention, healthspan
- MeSH
- humans, obesity, body mass index, caloric restriction, pilot projects, body composition, aging, aged, middle aged, female, male, overweight, intermittent fasting
15 autores
- Denise K. Houston🇺🇸 · autor de correspondenciaWake Forest University Health Sciences; Wake Forest University
- Jason T. Fanning🇺🇸Wake Forest University
- Barbara J. Nicklas🇺🇸Wake Forest University Health Sciences; Wake Forest University
- James P. DeLany🇺🇸AdventHealth Orlando
- Fang‐Chi Hsu🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Shyh-Huei Chen🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Michael P. Walkup🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Rebecca H. Neiberg🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Cynthia L. Stowe🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Kimberly Kennedy🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Mark Andrew Espeland🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Jamy D. Ard🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Michael E. Miller🇺🇸Wake Forest University Health Sciences; Wake Forest University
- W. Jack Rejeski🇺🇸Wake Forest University
- Stephen B. Kritchevsky🇺🇸Wake Forest University Health Sciences; Wake Forest University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life Outcomes Pilot (HALLO-P) was to inform the design of a definitive trial to evaluate the long-term effects of CR and TRE in older adults with overweight or obesity.
Methods
HALLO-P randomized 90 older (≥60 years) adults with obesity or overweight to one of three 9-month interventions: (1) 20% CR delivered in-person; (2) 20% CR delivered remotely (RCR); and (3) 8-hour TRE with ad libitum caloric intake. The degree of sustained CR (by doubly labeled water), the sustainability of TRE, participant retention, and changes in body mass and composition, physical performance, and cardiometabolic risk factors were examined.
Results
Participants had a mean (SD) age of 67.2 (4.9) years and BMI of 31.7 (2.9) kg/m2; 62% were female and 83% White. Participant retention was 92%. The mean (SD) percent CR was 4.5% (11.0) in CR and 6.0% (10.3) in RCR. TRE participants reported eating within an 8.5-hour window a median of 84% of days. Mean change in body mass was -4.4, -6.7, and -1.0 kg in CR, RCR, and TRE, respectively. CR and RCR lost fat and lean soft tissue. Chair stand and 400-m walk times improved in RCR and TRE, and there were improvements in glucose and cholesterol levels in all 3 groups.
Conclusions
HALLO-P showed that the CR and TRE interventions were feasible and associated with improvements in health status over 9 months despite not achieving the target CR.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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